Property Summary

NCBI Gene PubMed Count 57
PubMed Score 42.07
PubTator Score 52.24

Knowledge Summary

Patent (12,675)

TINX Plot

  Disease Sources (3)

Disease Target Count
Substance-Related Disorders 114
Disease Target Count P-value
non-small cell lung cancer 2798 3.11344274989141E-11
ependymoma 2514 4.76014455596763E-7
ovarian cancer 8492 9.38615527233923E-7
atypical teratoid / rhabdoid tumor 4369 3.73697050299951E-6
medulloblastoma, large-cell 6234 1.00107816475047E-5
pediatric high grade glioma 2712 1.55366244038941E-5
glioblastoma 5572 7.00818317584727E-5
primitive neuroectodermal tumor 3031 1.87993453218998E-4
osteosarcoma 7933 4.52574977937363E-4
Pick disease 1893 7.9508816829748E-4
intraductal papillary-mucinous adenoma (IPMA) 2956 9.81740197355477E-4
astrocytoma 1493 0.00186977840620554
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00188400457140255
primary pancreatic ductal adenocarcinoma 1271 0.00291675581771352
medulloblastoma 1524 0.00353207706704986
pancreatic cancer 2300 0.00834249601793706
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00917800084278621
subependymal giant cell astrocytoma 2287 0.0184664339317859
Disease Target Count Z-score Confidence
Cancer 2346 3.156 1.6

Expression

Synonym

Accession Q9BUB5 D3DQ20 D3DQ21 O00312 Q5TC06 Q5TC07 Q6V0N6
Symbols MNK1

Gene

PDB

2HW6   2Y9Q  

  Ortholog (8)

Species Source
Macaque OMA Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA Inparanoid
Cow OMA Inparanoid
Opossum OMA Inparanoid
Chicken OMA Inparanoid
Xenopus OMA Inparanoid

 MGI Term (1)

 GWAS Trait (1)

Gene RIF (35)

PMID Text
26668315 Data suggest MNK1/MNK2 stimulate mRNA translation but only of mRNA containing both 5-prime-terminal cap and hairpin duplex; this stimulation involves up-regulation of phosphorylation/mRNA un-winding activity of eIF4E (via decreased binding to eIF4G).
26147685 Data show that interferon-gamma regulated the metabolism and mRNA translation of macrophages by targeting the kinases mTORC1 and MNK1/2, both of which converge on the selective regulator of translation initiation eukaryotic initiation factor-4E (eIF4E).
25605250 Simultaneous targeting of androgen receptor and MNK1 by novel retinamides inhibits growth of human prostate cancer cell lines.
25527453 Data suggest that a combined pharmacologic inhibition of mTORC1 and Mnk1/2 kinases offers a therapeutic opportunity in blast crisis-chronic myeloid leukemia (BC-CML).
25403230 MNK1 and MNK2 inhibition ablates eIF4E1 phosphorylation and concurrently enhances eIF4E3 expression in diffuse large B-cell lymphoma.
25187541 ERK1/2 signal induced MNK catalytic activity enabled enterovirus type 1 internal ribosomal entry site-mediated translation/host cell cytotoxicity through negative regulation of the Ser/Arg (SR)-rich protein kinase (SRPK).
25187540 Authors show that MNK regulates SRPK via mTOR and AKT.
24714040 These data indicate multiple myeloma cells exploit the MNK/eIF-4E pathway for selective mRNA translation without enhancing global translation and risking ER stress.
24551240 High expression of p-Mnk1 and p-eIF4E might be novel valuable biomarkers to predict poor prognosis of nasopharyngeal carcinoma.
24401275 rapalog-activated MNK1 signaling promotes glioma growth through regulation of 4EBP1; there is a molecular cross-talk between the mTORC1 and MNK1 pathways
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AA Sequence

MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQ      1 - 70
NGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQK     71 - 140
HFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHR    141 - 210
DLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDK    211 - 280
RCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDL    281 - 350
ISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENEL    351 - 420
AEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL                             421 - 465
//

Text Mined References (60)

PMID Year Title
26668315 2016 Inhibition of Mitogen-activated Protein Kinase (MAPK)-interacting Kinase (MNK) Preferentially Affects Translation of mRNAs Containing Both a 5'-Terminal Cap and Hairpin.
26147685 2015 Interferon-? regulates cellular metabolism and mRNA translation to potentiate macrophage activation.
25605250 2015 Simultaneous targeting of androgen receptor (AR) and MAPK-interacting kinases (MNKs) by novel retinamides inhibits growth of human prostate cancer cell lines.
25527453 2015 Pharmacologic co-inhibition of Mnks and mTORC1 synergistically suppresses proliferation and perturbs cell cycle progression in blast crisis-chronic myeloid leukemia cells.
25403230 2014 MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL.
25187541 2014 Induction of viral, 7-methyl-guanosine cap-independent translation and oncolysis by mitogen-activated protein kinase-interacting kinase-mediated effects on the serine/arginine-rich protein kinase.
25187540 2014 Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis.
24714040 2014 MNK1-induced eIF-4E phosphorylation in myeloma cells: a pathway mediating IL-6-induced expansion and expression of genes involved in metabolic and proteotoxic responses.
24551240 2014 Phosphorylated Mnk1 and eIF4E are associated with lymph node metastasis and poor prognosis of nasopharyngeal carcinoma.
24401275 2014 MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas.
More...