| Tchem | MAP kinase-interacting serine/threonine-protein kinase 1 |
This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Substance-Related Disorders | 115 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 3.1e-11 |
| ependymoma | 4679 | 4.8e-07 |
| ovarian cancer | 8520 | 9.4e-07 |
| atypical teratoid / rhabdoid tumor | 5112 | 3.7e-06 |
| medulloblastoma, large-cell | 6241 | 1.0e-05 |
| primitive neuroectodermal tumor | 3035 | 1.9e-04 |
| osteosarcoma | 7950 | 4.5e-04 |
| Pick disease | 1894 | 8.0e-04 |
| glioblastoma | 5792 | 8.0e-04 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 9.8e-04 |
| astrocytoma | 1146 | 1.9e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 1.9e-03 |
| primary pancreatic ductal adenocarcinoma | 1109 | 6.7e-03 |
| pancreatic cancer | 2398 | 8.3e-03 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 9.2e-03 |
| adult high grade glioma | 3801 | 1.0e-02 |
| subependymal giant cell astrocytoma | 2287 | 1.1e-02 |
| group 3 medulloblastoma | 4104 | 3.4e-02 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -1.200 | 1.0e-02 |
| astrocytoma | 1.300 | 1.9e-03 |
| atypical teratoid / rhabdoid tumor | -2.100 | 3.7e-06 |
| ependymoma | -1.400 | 4.8e-07 |
| glioblastoma | -1.200 | 8.0e-04 |
| group 3 medulloblastoma | -1.100 | 3.4e-02 |
| intraductal papillary-mucinous adenoma (... | -1.700 | 9.8e-04 |
| intraductal papillary-mucinous carcinoma... | -1.700 | 1.9e-03 |
| intraductal papillary-mucinous neoplasm ... | -1.800 | 9.2e-03 |
| medulloblastoma, large-cell | -2.800 | 1.0e-05 |
| non-small cell lung cancer | -1.055 | 3.1e-11 |
| osteosarcoma | -1.415 | 4.5e-04 |
| ovarian cancer | -1.900 | 9.4e-07 |
| pancreatic cancer | -1.400 | 8.3e-03 |
| Pick disease | 1.100 | 8.0e-04 |
| primary pancreatic ductal adenocarcinoma | -1.102 | 6.7e-03 |
| primitive neuroectodermal tumor | -1.900 | 1.9e-04 |
| subependymal giant cell astrocytoma | 1.341 | 1.1e-02 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA |
CHEMBL1271532
pIC50 7.57
CHEMBL574738
pKd 7.59
CHEMBL478629
pIC50 7.96
CHEMBL3354999
pIC50 8.22
CHEMBL3354997
pIC50 8.22
CHEMBL3354998
pIC50 8.30
CHEMBL3797828
pIC50 8.40
CHEMBL3800585
pIC50 8.52
CHEMBL3798762
pIC50 8.70
CHEMBL3797873
pIC50 8.82
CHEMBL3355002
pIC50 9.00
CHEMBL3355000
pIC50 9.00
dorsomorphin
pIC50 7.96
MNK1 inhibitor
pIC50 6.06
MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQ 1 - 70 NGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQK 71 - 140 HFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHR 141 - 210 DLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDK 211 - 280 RCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDL 281 - 350 ISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENEL 351 - 420 AEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL 421 - 465 //
