Tbio CHRDL1 Chordin-like protein 1

Protein Summary

Description

Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development. This gene encodes an antagonist of bone morphogenetic protein 4. The encoded protein may play a role in topographic retinotectal projection and in the regulation of retinal angiogenesis in response to hypoxia. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009]

Uniprot Accession IDs

• Q9BU40
• B1AKD0
• B4DMP3
• D3DUY6
• E9PGS5
• Q539E4
• Q9Y3H7

Gene Name

• CHRDL1

Ensembl ID

• ENST00000372042
• ENSP00000361112
• ENSG00000101938
• ENST00000372045
• ENSP00000361115
• ENST00000394797
• ENSP00000378276
• ENST00000444321
• ENSP00000399739
• ENST00000482160
• ENSP00000418443

Symbol

• NRLN1
• CHL
• MGC1
• MGCN
• VOPT
• NRLN1
• dA141H5.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.63
gene perturbation	0.61
PubMedID	0.58
microRNA	0.57
small molecule perturbation	0.55

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.97   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 248   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.97   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 248   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0