Property Summary

NCBI Gene PubMed Count 17
PubMed Score 6.33
PubTator Score 8.94

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Relevance (2)

Disease Z-score Confidence
Anemia 252 4.127 2.1
ovarian cancer 8,484

Expression

  Differential Expression (1)

Disease log2 FC p
ovarian cancer -1.300 0.000

Synonym

Accession Q9BTP7 B3KY46 Q8WUJ7 Q96FX6
Symbols C19orf40

Gene

PDB

2LYH   2M9M   2M9N   4BXO   4M6W  

Gene RIF (9)

PMID Text
24003026 Results show that the first HhH motif of FAAP24 is a potential binding site for DNA, which plays a critical role in targeting FANCM-FAAP24 to chromatin.
23999858 These results demonstrate dual roles of FAAP24 in DNA damage response against crosslinking lesions, one through the formation of FANCM/FAAP24 heterodimer and the other via its ssDNA-binding activity required in optimized checkpoint activation.
23932590 Crystal structure of the FANCM-FAAP24 complex.
23333308 FANCM and FAAP24 play multiple, while not fully epistatic, roles in maintaining genomic integrity.
20670894 FANCM/FAAP24 plays a role in ICL-induced checkpoint activation through regulating RPA recruiment at ICL-stalled replication forks.
18995830 DNA damage recognition and remodeling activities of FANCM and FAAP24 cooperate to promote efficient activation of DNA damage checkpoints in Fanconi anemia.
18206976 FAAP24 is dispensable for DNA binding and branch migration activity of FANCM.
18174376 FANCM is an anchor required for recruitment of the FA core complex to chromatin, and the FANCM/FAAP24 interaction is essential for this chromatin-loading activity
17289582 FAAP24 targets FANCM to structures that mimic intermediates formed during the replication/repair of damaged DNA.

AA Sequence

MEKNPPDDTGPVHVPLGHIVANEKWRGSQLAQEMQGKIKLIFEDGLTPDFYLSNRCCILYVTEADLVAGN      1 - 70
GYRKRLVRVRNSNNLKGIVVVEKTRMSEQYFPALQKFTVLDLGMVLLPVASQMEASCLVIQLVQEQTKEP     71 - 140
SKNPLLGKKRALLLSEPSLLRTVQQIPGVGKVKAPLLLQKFPSIQQLSNASIGELEQVVGQAVAQQIHAF    141 - 210
FTQPR                                                                     211 - 215
//

Text Mined References (18)

PMID Year Title
26871637 2016 Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
24003026 2013 Structural insights into the functions of the FANCM-FAAP24 complex in DNA repair.
23999858 2013 Structure analysis of FAAP24 reveals single-stranded DNA-binding activity and domain functions in DNA damage response.
23932590 2013 Architecture and DNA recognition elements of the Fanconi anemia FANCM-FAAP24 complex.
23333308 2013 FANCM and FAAP24 maintain genome stability via cooperative as well as unique functions.
20670894 2010 The FANCM/FAAP24 complex is required for the DNA interstrand crosslink-induced checkpoint response.
20347429 2010 MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM.
20347428 2010 A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability.
18995830 2008 FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex.
18206976 2008 The Fanconi anemia protein FANCM can promote branch migration of Holliday junctions and replication forks.
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