| Tbio | BTB/POZ domain-containing protein 10 |
Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| atypical teratoid / rhabdoid tumor | 5112 | 8.3e-07 |
| medulloblastoma | 720 | 1.1e-06 |
| glioblastoma | 5792 | 3.5e-06 |
| Astrocytoma, Pilocytic | 3081 | 1.9e-05 |
| osteosarcoma | 7950 | 3.8e-05 |
| medulloblastoma, large-cell | 6241 | 9.1e-05 |
| adult high grade glioma | 3801 | 8.3e-04 |
| primary pancreatic ductal adenocarcinoma | 1109 | 1.3e-03 |
| astrocytic glioma | 2597 | 1.3e-03 |
| ependymoma | 4679 | 6.9e-03 |
| Breast cancer | 3578 | 2.9e-02 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 3.6e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Amyotrophic lateral sclerosis | 451 | 3.251 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -1.200 | 8.3e-04 |
| astrocytic glioma | -1.500 | 1.3e-03 |
| Astrocytoma, Pilocytic | -1.100 | 1.9e-05 |
| atypical teratoid / rhabdoid tumor | -1.500 | 8.3e-07 |
| Breast cancer | 2.500 | 2.9e-02 |
| ependymoma | -1.100 | 6.9e-03 |
| glioblastoma | -1.500 | 3.5e-06 |
| intraductal papillary-mucinous neoplasm ... | 1.900 | 3.6e-02 |
| medulloblastoma | -1.400 | 1.1e-06 |
| medulloblastoma, large-cell | -1.900 | 9.1e-05 |
| osteosarcoma | -1.195 | 3.8e-05 |
| primary pancreatic ductal adenocarcinoma | 1.374 | 1.3e-03 |
MAGRPHPYDGNSSDPENWDRKLHSRPRKLYKHSSTSSRIAKGGVDHTKMSLHGASGGHERSRDRRRSSDR 1 - 70 SRDSSHERTESQLTPCIRNVTSPTRQHHVEREKDHSSSRPSSPRPQKASPNGSISSAGNSSRNSSQSSSD 71 - 140 GSCKTAGEMVFVYENAKEGARNIRTSERVTLIVDNTRFVVDPSIFTAQPNTMLGRMFGSGREHNFTRPNE 141 - 210 KGEYEVAEGIGSTVFRAILDYYKTGIIRCPDGISIPELREACDYLCISFEYSTIKCRDLSALMHELSNDG 211 - 280 ARRQFEFYLEEMILPLMVASAQSGERECHIVVLTDDDVVDWDEEYPPQMGEEYSQIIYSTKLYRFFKYIE 281 - 350 NRDVAKSVLKERGLKKIRLGIEGYPTYKEKVKKRPGGRPEVIYNYVQRPFIRMSWEKEEGKSRHVDFQCV 351 - 420 KSKSITNLAAAAADIPQDQLVVMHPTPQVDELDILPIHPPSGNSDLDPDAQNPML 421 - 475 //
