| Tbio | BTB/POZ domain-containing protein 10 |
Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells.
Comments
| Disease | log2 FC | p |
|---|---|---|
| astrocytic glioma | -1.500 | 0.001 |
| ependymoma | -1.300 | 0.000 |
| osteosarcoma | -1.195 | 0.000 |
| atypical teratoid / rhabdoid tumor | -1.500 | 0.000 |
| glioblastoma | -1.500 | 0.000 |
| medulloblastoma | -1.400 | 0.000 |
| medulloblastoma, large-cell | -1.900 | 0.000 |
| primary pancreatic ductal adenocarcinoma | 1.374 | 0.001 |
| intraductal papillary-mucinous neoplasm ... | 1.900 | 0.036 |
| Breast cancer | 2.500 | 0.029 |
| adult high grade glioma | -1.200 | 0.001 |
| pilocytic astrocytoma | -1.100 | 0.000 |
| PMID | Text |
|---|---|
| 23320755 | findings suggest that reduced BTBD10 expression is closely linked to the pathogenesis of sporadic amyotrophic lateral sclerosis |
| 22388351 | Collectively, these results suggest that the reduced expression of BTBD10 leads to motor neuron death both in vitro and in vivo. |
| 21267538 | GMRP1 regulates pancreatic beta cell proliferation and apoptosis via activation of Akt signalling pathway. |
| 20379614 | Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 18160256 | BTBD10 appears to behave as a suppressor of cell death including neuronal cell death related to amyotrophic lateral sclerosis and an enhancer of cell growth via its positive regulation of Akt phosphorylation. |
MAGRPHPYDGNSSDPENWDRKLHSRPRKLYKHSSTSSRIAKGGVDHTKMSLHGASGGHERSRDRRRSSDR 1 - 70 SRDSSHERTESQLTPCIRNVTSPTRQHHVEREKDHSSSRPSSPRPQKASPNGSISSAGNSSRNSSQSSSD 71 - 140 GSCKTAGEMVFVYENAKEGARNIRTSERVTLIVDNTRFVVDPSIFTAQPNTMLGRMFGSGREHNFTRPNE 141 - 210 KGEYEVAEGIGSTVFRAILDYYKTGIIRCPDGISIPELREACDYLCISFEYSTIKCRDLSALMHELSNDG 211 - 280 ARRQFEFYLEEMILPLMVASAQSGERECHIVVLTDDDVVDWDEEYPPQMGEEYSQIIYSTKLYRFFKYIE 281 - 350 NRDVAKSVLKERGLKKIRLGIEGYPTYKEKVKKRPGGRPEVIYNYVQRPFIRMSWEKEEGKSRHVDFQCV 351 - 420 KSKSITNLAAAAADIPQDQLVVMHPTPQVDELDILPIHPPSGNSDLDPDAQNPML 421 - 475 //
| PMID | Year | Title |
|---|---|---|
| 23320755 | 2013 | Reduced expression of BTBD10 in anterior horn cells with Golgi fragmentation and pTDP-43-positive inclusions in patients with sporadic amyotrophic lateral sclerosis. |
| 22388351 | 2012 | Reduced expression of BTBD10, an Akt activator, leads to motor neuron death. |
| 21406692 | 2011 | System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. |
| 21267538 | 2011 | Glucose metabolism-related protein 1 (GMRP1) regulates pancreatic beta cell proliferation and apoptosis via activation of Akt signalling pathway in rats and mice. |
| 20379614 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | |
| 18160256 | 2008 | A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB. |
| 18029348 | 2008 | Toward a confocal subcellular atlas of the human proteome. |
| 17974005 | 2007 | The full-ORF clone resource of the German cDNA Consortium. |
| 16554811 | 2006 | Human chromosome 11 DNA sequence and analysis including novel gene identification. |
| 16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |
| More... |
