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Tdark Transmembrane protein 79

Contributes to the epidermal integrity and skin barrier function. Plays a role in the lamellar granule (LG) secretory system and in the stratum corneum (SC) epithelial cell formation (By similarity).

 Comments

Property Summary

NCBI Gene PubMed Count 14
PubMed Score 91.10
PubTator Score 4.56

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
non-small cell lung cancer 2798 9.11017717519645E-15
psoriasis 6685 8.21270960391107E-12
osteosarcoma 7933 2.80208793440445E-7
ovarian cancer 8492 1.43506461411499E-6
interstitial cystitis 2299 1.31539836327452E-4
ductal carcinoma in situ 1745 6.56887183856231E-4
invasive ductal carcinoma 2950 0.0118802124341081
spina bifida 1064 0.039480687104631
Disease Target Count Z-score Confidence
Angular cheilitis 3 4.029 2.0
Glossitis 3 3.55 1.8
Atopic dermatitis 944 3.463 1.7

Expression

  Differential Expression (8)

Disease log2 FC p
osteosarcoma -1.301 0.000
non-small cell lung cancer 1.682 0.000
interstitial cystitis -1.400 0.000
psoriasis 1.200 0.000
spina bifida -1.659 0.039
ductal carcinoma in situ 1.600 0.001
invasive ductal carcinoma 1.300 0.012
ovarian cancer 1.100 0.000

Synonym

Accession Q9BSE2 B2RE22 D3DVB8
Symbols MATT

Gene

TMEM79

  Ortholog (8)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG
Anole lizard OMA EggNOG Inparanoid

 GO Component (3)

 GO Process (7)

 Compartment GO Term (36)

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 IMPC Term (8)

 MGI Term (9)

 HCA RNA Cell Line (56)

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Pathway (1)

 UniProt Keyword (8)

Gene RIF (2)

PMID Text
26237329 The study identified two proteins, TMEM79 and ACOXL, with potential to differentiate between benign and cancerous prostatic glands in tissue biopsies.
24084074 Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects.

AA Sequence 

MTEQETLALLEVKRSDSPEKSSPQALVPNGRQPEGEGGAESPGAESLRVGSSAGSPTAIEGAEDGLDSTV      1 - 70
SEAATLPWGTGPQPSAPFPDPPGWRDIEPEPPESEPLTKLEELPEDDANLLPEKAARAFVPIDLQCIERQ     71 - 140
PQEDLIVRCEAGEGECRTFMPPRVTHPDPTERKWAEAVVRPPGCSCGGCGSCGDREWLRAVASVGAALIL    141 - 210
FPCLLYGAYAFLPFDVPRLPTMSSRLIYTLRCGVFATFPIVLGILVYGLSLLCFSALRPFGEPRREVEIH    211 - 280
RRYVAQSVQLFILYFFNLAVLSTYLPQDTLKLLPLLTGLFAVSRLIYWLTFAVGRSFRGFGYGLTFLPLL    281 - 350
SMLMWNLYYMFVVEPERMLTATESRLDYPDHARSASDYRPRPWG                              351 - 394
//

Text Mined References (15)

PMID Year Title
26237329 2015 Analysis of the Human Prostate-Specific Proteome Defined by Transcriptomics and Antibody-Based Profiling Identifies TMEM79 and ACOXL as Two Putative, Diagnostic Markers in Prostate Cancer.
25416956 2014 A proteome-scale map of the human interactome network.
25131691 2014 Mechanisms of abnormal lamellar body secretion and the dysfunctional skin barrier in patients with atopic dermatitis.
24647736 2014 Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians.
24084074 2013 Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects.
24060273 2013 A homozygous nonsense mutation in the gene for Tmem79, a component for the lamellar granule secretory system, produces spontaneous eczema in an experimental model of atopic dermatitis.
21516116 2011 Next-generation sequencing to generate interactome datasets.
20139978 2010 Genome-wide association study of hematological and biochemical traits in a Japanese population.
17207965 2007 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
17081983 2006 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
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