Tdark | Transmembrane protein 79 |
Contributes to the epidermal integrity and skin barrier function. Plays a role in the lamellar granule (LG) secretory system and in the stratum corneum (SC) epithelial cell formation (By similarity).
Comments
Disease | Target Count | P-value |
---|---|---|
non-small cell lung cancer | 2798 | 9.11017717519645E-15 |
psoriasis | 6685 | 8.21270960391107E-12 |
osteosarcoma | 7933 | 2.80208793440445E-7 |
ovarian cancer | 8492 | 1.43506461411499E-6 |
interstitial cystitis | 2299 | 1.31539836327452E-4 |
ductal carcinoma in situ | 1745 | 6.56887183856231E-4 |
invasive ductal carcinoma | 2950 | 0.0118802124341081 |
spina bifida | 1064 | 0.039480687104631 |
Disease | log2 FC | p |
---|---|---|
osteosarcoma | -1.301 | 0.000 |
non-small cell lung cancer | 1.682 | 0.000 |
interstitial cystitis | -1.400 | 0.000 |
psoriasis | 1.200 | 0.000 |
spina bifida | -1.659 | 0.039 |
ductal carcinoma in situ | 1.600 | 0.001 |
invasive ductal carcinoma | 1.300 | 0.012 |
ovarian cancer | 1.100 | 0.000 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA EggNOG Inparanoid |
Dog | OMA EggNOG Inparanoid |
Cow | OMA EggNOG Inparanoid |
Opossum | OMA EggNOG Inparanoid |
Platypus | OMA EggNOG |
Anole lizard | OMA EggNOG Inparanoid |
MTEQETLALLEVKRSDSPEKSSPQALVPNGRQPEGEGGAESPGAESLRVGSSAGSPTAIEGAEDGLDSTV 1 - 70 SEAATLPWGTGPQPSAPFPDPPGWRDIEPEPPESEPLTKLEELPEDDANLLPEKAARAFVPIDLQCIERQ 71 - 140 PQEDLIVRCEAGEGECRTFMPPRVTHPDPTERKWAEAVVRPPGCSCGGCGSCGDREWLRAVASVGAALIL 141 - 210 FPCLLYGAYAFLPFDVPRLPTMSSRLIYTLRCGVFATFPIVLGILVYGLSLLCFSALRPFGEPRREVEIH 211 - 280 RRYVAQSVQLFILYFFNLAVLSTYLPQDTLKLLPLLTGLFAVSRLIYWLTFAVGRSFRGFGYGLTFLPLL 281 - 350 SMLMWNLYYMFVVEPERMLTATESRLDYPDHARSASDYRPRPWG 351 - 394 //
PMID | Year | Title |
---|---|---|
26237329 | 2015 | Analysis of the Human Prostate-Specific Proteome Defined by Transcriptomics and Antibody-Based Profiling Identifies TMEM79 and ACOXL as Two Putative, Diagnostic Markers in Prostate Cancer. |
25416956 | 2014 | A proteome-scale map of the human interactome network. |
25131691 | 2014 | Mechanisms of abnormal lamellar body secretion and the dysfunctional skin barrier in patients with atopic dermatitis. |
24647736 | 2014 | Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians. |
24084074 | 2013 | Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects. |
24060273 | 2013 | A homozygous nonsense mutation in the gene for Tmem79, a component for the lamellar granule secretory system, produces spontaneous eczema in an experimental model of atopic dermatitis. |
21516116 | 2011 | Next-generation sequencing to generate interactome datasets. |
20139978 | 2010 | Genome-wide association study of hematological and biochemical traits in a Japanese population. |
17207965 | 2007 | hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. |
17081983 | 2006 | Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |
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