Tbio | Autophagy-related protein 101 |
Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation.
Comments
Disease | Target Count | P-value |
---|---|---|
ovarian cancer | 8492 | 2.63759804075612E-6 |
psoriasis | 6685 | 9.01581124920151E-4 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Spinocerebellar ataxia type 7 | 13 | 3.702 | 1.9 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Macaque | OMA EggNOG |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA EggNOG Inparanoid |
Dog | OMA EggNOG |
Cow | OMA EggNOG Inparanoid |
Anole lizard | OMA EggNOG |
C. elegans | OMA EggNOG Inparanoid |
PMID | Text |
---|---|
26299944 | Structure of the human Atg13-Atg101 HORMA heterodimer in the ULK1 complex that controls autophagy has been described. |
23640897 | Data indicate mitogen lacritin stimulates FOXO3-ATG101 and FOXO1-ATG7 autophagic coupling and restores metabolic homeostasis. |
19597335 | These data suggest that Atg101 is a novel Atg protein that functions together with ULK, Atg13 and FIP200. |
19287211 | The identification of the novel protein, Atg101, and the validation of Atg13 and Atg101 as ULK1-interacting proteins, suggests an Atg1 complex is involved in the induction of macroautophagy in mammalian cells. |
PMID | Year | Title |
---|---|---|
26299944 | 2015 | Structure of the Human Atg13-Atg101 HORMA Heterodimer: an Interaction Hub within the ULK1 Complex. |
26236954 | 2015 | The mammalian autophagy initiator complex contains 2 HORMA domain proteins. |
23640897 | 2013 | Lacritin rescues stressed epithelia via rapid forkhead box O3 (FOXO3)-associated autophagy that restores metabolism. |
23392225 | 2013 | FIP200 regulates targeting of Atg16L1 to the isolation membrane. |
21269460 | 2011 | Initial characterization of the human central proteome. |
20562859 | 2010 | Network organization of the human autophagy system. |
19597335 | 2009 | Atg101, a novel mammalian autophagy protein interacting with Atg13. |
19287211 | 2009 | A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy. |
16712791 | 2006 | Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. |
16541075 | 2006 | The finished DNA sequence of human chromosome 12. |
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