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Tbio
TMEM175
Endosomal/lysosomal potassium channel TMEM175

Protein Summary
Description
Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes. Forms a potassium-permeable leak-like channel, which regulates lumenal pH stability and is required for autophagosome-lysosome fusion. Constitutes the major lysosomal potassium channel.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264771
  • ENSP00000264771
  • ENSG00000127419
  • ENST00000515740
  • ENSP00000427039
  • ENST00000622959
  • ENSP00000485461

Symbol
  • hTMEM175
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.67
kinase perturbation
0.66
tissue sample
0.63
transcription factor binding site profile
0.62
cell line
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.78   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 54   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.78   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0