Property Summary

NCBI Gene PubMed Count 12
PubMed Score 5.61
PubTator Score 9.49

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count
Prostatic Neoplasms 471
Disease Target Count P-value
Breast cancer 3099 3.16478979872386E-69
breast carcinoma 1614 2.46205442492381E-32
psoriasis 6685 1.18149946431447E-20
ovarian cancer 8492 8.9438383915108E-19
non-small cell lung cancer 2798 4.86811081769402E-12
Duchenne muscular dystrophy 602 1.24568726956132E-10
oligodendroglioma 2849 1.39981841511399E-10
juvenile dermatomyositis 1189 9.0684536419985E-10
atypical teratoid / rhabdoid tumor 4369 1.2105613093889E-7
autosomal dominant Emery-Dreifuss muscular dystrophy 499 3.2271169594129E-5
glioblastoma 5572 9.23670177872688E-5
cystic fibrosis 1670 1.16478463340367E-4
adult high grade glioma 2148 1.31185004673282E-4
Pick disease 1893 2.21516995961618E-4
Amyotrophic Lateral Sclerosis 432 2.82811589393612E-4
medulloblastoma, large-cell 6234 4.68645728040452E-4
invasive ductal carcinoma 2950 5.07794351388797E-4
intraductal papillary-mucinous adenoma (IPMA) 2956 7.05433745202976E-4
intraductal papillary-mucinous carcinoma (IPMC) 2988 7.87628962790139E-4
fascioscapulohumeral muscular dystrophy 100 7.97208212287847E-4
Atopic dermatitis 944 8.78907693162949E-4
astrocytic glioma 2241 0.00681862188519825
adrenocortical adenoma 134 0.00924281748348832
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00956165418407629
limb girdle muscular dystrophy 2B 74 0.0109925639238066
ependymoma 2514 0.0185269376506593
aldosterone-producing adenoma 664 0.0194336052116788
adrenocortical carcinoma 1427 0.0199653431235962
ductal carcinoma in situ 1745 0.0293332291756718
group 3 medulloblastoma 2254 0.037610390704842



Accession Q9BRU2 B3KSV2 Q96AT4 TCEA-like protein 7
Symbols WEX5


PANTHER Protein Class (1)

  Ortholog (6)

Gene RIF (7)

23372750 Our study suggests that TCEAL7 might serve as a candidate tumor suppressor and a potential prognostic biomarker in gastric carcinogenesis.
20454512 alteration of TCEAL7 expression levels in recombination-based alternative lengthening of telomeres and telomerase-positive cells affects hTERT expression
19966855 TCEAL7 in the negative regulation of NF-kappaB signaling at the basal level by modulating transcriptional activity of NF-kappaB on its target gene promoters in ovarian cells.
19419758 TCEAL7 polymorphisms may play a role in the development of invasive serous ovarian cancers.
19419758 Observational study of gene-disease association. (HuGE Navigator)
18806825 A role for candidate tumor-suppressor gene TCEAL7 in the regulation of c-Myc activity, cyclin D1 levels and cellular transformation is reported.
15870691 TCEAL7 is a cell death regulatory protein that is frequently inactivated in ovarian cancers, and may function as a tumor suppressor.

AA Sequence

RCLEEIRGLRKKFRALHSNHRHSRDRPYPI                                             71 - 100

Text Mined References (12)

PMID Year Title
23372750 2013 Decreased expression of transcription elongation factor A-like 7 is associated with gastric adenocarcinoma prognosis.
20454512 2010 TCEAL7 inhibition of c-Myc activity in alternative lengthening of telomeres regulates hTERT expression.
19966855 2010 TCEAL7, a putative tumor suppressor gene, negatively regulates NF-kappaB pathway.
19419758 2009 Polymorphisms in TCEAL7 and risk of epithelial ovarian cancer.
18806825 2008 A role for candidate tumor-suppressor gene TCEAL7 in the regulation of c-Myc activity, cyclin D1 levels and cellular transformation.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
16221301 2005 Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events.
15870691 2005 Epigenetic silencing of TCEAL7 (Bex4) in ovarian cancer.
15772651 2005 The DNA sequence of the human X chromosome.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).