| Tbio | Migration and invasion enhancer 1 |
Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| breast carcinoma | 1614 | 8.55962642351498E-14 |
| ovarian cancer | 8492 | 1.58461067915306E-4 |
| invasive ductal carcinoma | 2950 | 0.0334789724685033 |
| Breast cancer | 3099 | 0.0393249929131534 |
| Disease | log2 FC | p |
|---|---|---|
| Breast cancer | 2.100 | 0.039 |
| breast carcinoma | 1.100 | 0.000 |
| invasive ductal carcinoma | 2.300 | 0.033 |
| ovarian cancer | 1.700 | 0.000 |
| Accession | Q9BRT3 |
| Symbols |
C35 ORB3 XTP4 RDX12 C17orf37 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA EggNOG |
| Dog | OMA EggNOG |
| Horse | OMA EggNOG Inparanoid |
| Cow | OMA EggNOG Inparanoid |
| Pig | OMA EggNOG |
| Anole lizard | OMA EggNOG Inparanoid |
| Xenopus | OMA EggNOG |
| Fruitfly | EggNOG Inparanoid |
| PMID | Text |
|---|---|
| 26827826 | In conclusion, this study revealed that miR-26b suppresses NSCLC metastasis by targeting MIEN1 via NF-kappaB/MMP-9/VEGF pathways, implicating a potential prognostic biomarker and therapeutic target for NSCLC treatment. |
| 26272794 | MIEN1, a novel interactor of Annexin A2, promotes tumor cell migration by enhancing AnxA2 cell surface expression. |
| 26173296 | C35 might serve as a biomarker or therapeutic target for management of colorectal cancer. |
| 25996585 | MIEN1 expression not only positively correlates with oral cancer progression but also seems to be a critical molecular determinant in migration and invasion of oral cancer cells. |
| 25406943 | While MIEN1 is a direct target of miR-940, miR-940 alters MIEN1 RNA. |
| 23880825 | results suggest that DeltaNp73 might cooperate with C35 to promote tumour progression and contribute to cisplatin resistance in ovarian cancer cells. |
| 23284973 | Results suggest that MIEN1 may have an important regulatory role in phosphorylation of AKT with its redox potential. |
| 21628459 | prenylation is required for the function of the C17orf37 protein in cancer cells |
| 21068479 | Inhibition of C35 gene expression by small interfering RNA induces apoptosis of breast cancer cells. |
| 19503095 | Data strongly suggest C17orf37 overexpression in prostate cancer functionally enhances migration and invasion of tumor cells, and is an important target for cancer therapy. |
| More... |
| PMID | Year | Title |
|---|---|---|
| 26827826 | 2016 | MicroRNA-26b suppresses the metastasis of non-small cell lung cancer by targeting MIEN1 via NF-?B/MMP-9/VEGF pathways. |
| 26272794 | 2015 | MIEN1, a novel interactor of Annexin A2, promotes tumor cell migration by enhancing AnxA2 cell surface expression. |
| 26173296 | 2015 | C35 is overexpressed in colorectal cancer and is associated tumor invasion and metastasis. |
| 25996585 | 2015 | MIEN1 promotes oral cancer progression and implicates poor overall survival. |
| 25416956 | 2014 | A proteome-scale map of the human interactome network. |
| 25406943 | 2014 | MicroRNA-940 suppresses prostate cancer migration and invasion by regulating MIEN1. |
| 23880825 | 2013 | The interaction between C35 and ?Np73 promotes chemo-resistance in ovarian cancer cells. |
| 23376485 | 2013 | Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. |
| 23284973 | 2012 | Solution structure of the oncogenic MIEN1 protein reveals a thioredoxin-like fold with a redox-active motif. |
| 22814378 | 2012 | N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. |
| More... |
