Property Summary

NCBI Gene PubMed Count 17
PubMed Score 25.60
PubTator Score 28.22

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count P-value
oligodendroglioma 2849 1.7566579945861E-13
juvenile dermatomyositis 1189 5.19552566406272E-10
psoriasis 6685 1.01143385381107E-9
atypical teratoid/rhabdoid tumor 1095 6.46708035571852E-9
malignant mesothelioma 3163 1.70459641731204E-8
pilocytic astrocytoma 3086 3.38576615148202E-8
lung carcinoma 2844 4.94423063236654E-8
group 3 medulloblastoma 2254 7.32423465878292E-8
non-small cell lung cancer 2798 1.26012143203254E-7
pediatric high grade glioma 2712 1.72957448217831E-7
glioblastoma 5572 3.39280190860251E-7
osteosarcoma 7933 4.24101776637323E-7
breast carcinoma 1614 1.48730243891417E-6
lung adenocarcinoma 2714 5.79100177201944E-6
medulloblastoma, large-cell 6234 3.12652422556939E-5
ductal carcinoma in situ 1745 2.35215800807359E-4
ovarian cancer 8492 4.44355873011378E-4
ulcerative colitis 2087 7.74203086289852E-4
primitive neuroectodermal tumor 3031 0.00133480970474262
fibroadenoma 557 0.00227514105724786
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00562936199629971
invasive ductal carcinoma 2950 0.00586816041721893
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0062441116622207
astrocytic glioma 2241 0.006437115704487
ependymoma 2514 0.00936094351109476
subependymal giant cell astrocytoma 2287 0.0112517622693667
Pick disease 1893 0.0129947152871742
progressive supranuclear palsy 674 0.0198417257388034
non-inflammatory breast cancer 208 0.0214769997378193
pancreatic ductal adenocarcinoma liver metastasis 1795 0.0275348515342623
Disease Target Count Z-score Confidence
Type 2 diabetes mellitus 192 0.0 2.0
Disease Target Count Z-score Confidence
Lupus erythematosus 80 3.083 1.5



Accession Q9BRS8 Q5XKE4 Q8N3N2 Q9NUR0
Symbols ACHN



2MTF   2MTG  

  Ortholog (11)

Gene RIF (10)

25692237 Data indicate that LA motif protein LARP6 binding to spliced leader RNA (5'SL) of collagen alpha2(I) mRNA is more stable than the binding to 5'SL of alpha1(I) mRNA.
25488812 The study presents the structure of the La motif and RRM1 of human LARP6 uncovering in both cases considerable structural variation in comparison to the equivalent domains in La and revealing an unprecedented fold for the RRM1.
25271881 We postulate that collagen mRNAs directly partition to the endoplasmic reticulum membrane prior to synthesis of the signal peptide and that LARP6 and nonmuscle myosin filaments mediate this process.
24469459 LARP6 is a critical mediator by which IGF-1 augments synthesis of collagen type I in vascular smooth muscle
23887937 The results demonstrate that the La modules of the human LARP6 is also active in tRNA-mediated suppression, even in the absence of stable UUU-3'OH trailer protection.
22139627 Acheron regulates vascular endothelial proliferation and angiogenesis together with Id1 during wound healing.
21387291 Achn enhances human breast tumor growth and vascularization and that this activity is dependent on nuclear localization.
19917293 LARP6 has a distinctive bipartite RNA binding domain not found in other members of the La superfamily. LARP6 interacts with the two single-stranded regions of the 5' stem-loop.
19889961 Acheron may influence differentiation in part via its control of cell adhesion dynamics.
17383118 These data define Achn as a newly discovered regulatory molecule that presumably mediates a variety of developmental and homeostatic processes in animals.

AA Sequence


Text Mined References (24)

PMID Year Title
25692237 2014 Characterization of binding of LARP6 to the 5' stem-loop of collagen mRNAs: implications for synthesis of type I collagen.
25488812 2015 Synergic interplay of the La motif, RRM1 and the interdomain linker of LARP6 in the recognition of collagen mRNA expands the RNA binding repertoire of the La module.
25271881 2014 Role of LARP6 and nonmuscle myosin in partitioning of collagen mRNAs to the ER membrane.
24469459 2014 Insulin-like growth factor-1 increases synthesis of collagen type I via induction of the mRNA-binding protein LARP6 expression and binding to the 5' stem-loop of COL1a1 and COL1a2 mRNA.
23887937 2013 Conservation of RNA chaperone activity of the human La-related proteins 4, 6 and 7.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22190748 2012 A novel role of RNA helicase A in regulation of translation of type I collagen mRNAs.
22139627 2011 Acheron regulates vascular endothelial proliferation and angiogenesis together with Id1 during wound healing.
21873549 2011 Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
21746880 2011 A novel role of vimentin filaments: binding and stabilization of collagen mRNAs.
21387291 2012 The novel lupus antigen related protein acheron enhances the development of human breast cancer.
20603131 2010 Nonmuscle myosin-dependent synthesis of type I collagen.
19917293 2010 Binding of LARP6 to the conserved 5' stem-loop regulates translation of mRNAs encoding type I collagen.
19889961 2010 Acheron, a Lupus antigen family member, regulates integrin expression, adhesion, and motility in differentiating myoblasts.
19413330 2009 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
17974005 2007 The full-ORF clone resource of the German cDNA Consortium.
17383118 2007 Acheron, a novel member of the Lupus Antigen family, is induced during the programmed cell death of skeletal muscles in the moth Manduca sexta.
17081983 2006 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
16572171 2006 Analysis of the DNA sequence and duplication history of human chromosome 15.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.