Tchem RIOK1 Serine/threonine-protein kinase RIO1

Protein Summary

Description

Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor (PubMed:22072790). The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its dynamic association with the 40S subunit (By similarity). In addition to its role in ribosomal biogenesis acts as an adapter protein by recruiting NCL/nucleolin the to PRMT5 complex for its symmetrical methylation (PubMed:21081503). The protein encoded by this gene competes with pICln for inclusion in the protein arginine methyltransferase 5 complex. This complex targets substrates for dimethylation. The encoded protein is essential for the last steps in the maturation of 40S subunits. [provided by RefSeq, Jan 2017]

Uniprot Accession IDs

• Q9BRS2
• B2RB28
• Q8NDC8
• Q96NV9

Gene Name

• RIOK1

Ensembl ID

• ENST00000379834
• ENSP00000369162
• ENSG00000124784

Symbol

• RIO1
• RIO1
• AD034
• RRP10
• bA288G3.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.98
molecular function	0.9
histone modification site profile	0.87
small molecule	0.8
transcription factor binding site profile	0.77

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Atypical Group / Rio Family / Rio1 Subfamily / Serine/threonine-protein Kinase Rio1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.37   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 183   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.37   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1