Property Summary

NCBI Gene PubMed Count 19
PubMed Score 16.21
PubTator Score 13.28

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (1)

Disease Target Count P-value
non-small cell lung cancer 2798 6.62154993964306E-10
lung adenocarcinoma 2714 1.04347091143008E-5
ductal carcinoma in situ 1745 1.61198771425675E-4
invasive ductal carcinoma 2950 0.00725278792800329
breast carcinoma 1614 0.00936307489938179
pancreatic ductal adenocarcinoma liver metastasis 1795 0.0293031010235808
fibroadenoma 557 0.0295845314767826

Expression

  Differential Expression (7)

Disease log2 FC p
pancreatic ductal adenocarcinoma liver m... -1.395 0.029
non-small cell lung cancer 1.036 0.000
breast carcinoma -1.400 0.009
fibroadenoma -2.300 0.030
lung adenocarcinoma 1.100 0.000
ductal carcinoma in situ -2.800 0.000
invasive ductal carcinoma -2.100 0.007

Synonym

Accession Q9BRQ8 B3KXI0 Q63Z39
Symbols AMID
PRG3

Gene

  Ortholog (10)

Species Source
Macaque OMA Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA Inparanoid
Dog OMA Inparanoid
Horse OMA Inparanoid
Cow OMA Inparanoid
Platypus OMA EggNOG
Chicken OMA Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA Inparanoid

 MGI Term (1)

Gene RIF (11)

PMID Text
26063804 AIF and its family member protein, AMID, are rotenone-sensitive NADH:ubiquinone oxidoreductases (of the NDH-2 type).
25244912 HUHS1015 increased nuclear localization of apoptosis-inducing factor-homologous mitochondrion-associated inducer of death (AMID).
20877624 Observational study of gene-disease association. (HuGE Navigator)
20635389 Observational study of gene-disease association. (HuGE Navigator)
19270026 Observational study of gene-disease association. (HuGE Navigator)
17711848 AIF-M2 lessens survival cell signaling in the presence of foreign (e.g. bacterial and (retro)viral) cytosolic DNA, thus contributing to the onset of apoptosis
17347867 study of cellular localization of the endonuclease G, AIF & AMID during apoptosis using bioinformatics and image analysis
15958387 Reasults establish a link between coenzyme and DNA binding that likely impacts on the physiological role of AMID in cellular apoptosis.
15273740 AMID is a p53-downstream gene involved in tumorigenesis.
12135761 encodes a homologue of the apoptosis-inducing factor
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AA Sequence

MGSQVSVESGALHVVIVGGGFGGIAAASQLQALNVPFMLVDMKDSFHHNVAALRASVETGFAKKTFISYS      1 - 70
VTFKDNFRQGLVVGIDLKNQMVLLQGGEALPFSHLILATGSTGPFPGKFNEVSSQQAAIQAYEDMVRQVQ     71 - 140
RSRFIVVVGGGSAGVEMAAEIKTEYPEKEVTLIHSQVALADKELLPSVRQEVKEILLRKGVQLLLSERVS    141 - 210
NLEELPLNEYREYIKVQTDKGTEVATNLVILCTGIKINSSAYRKAFESRLASSGALRVNEHLQVEGHSNV    211 - 280
YAIGDCADVRTPKMAYLAGLHANIAVANIVNSVKQRPLQAYKPGALTFLLSMGRNDGVGQISGFYVGRLM    281 - 350
VRLTKSRDLFVSTSWKTMRQSPP                                                   351 - 373
//

Text Mined References (23)

PMID Year Title
26063804 2015 Apoptosis-inducing Factor (AIF) and Its Family Member Protein, AMID, Are Rotenone-sensitive NADH:Ubiquinone Oxidoreductases (NDH-2).
25255805 2014 Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.
25244912 2015 HUHS1015 induces necroptosis and caspase-independent apoptosis of MKN28 human gastric cancer cells in association with AMID accumulation in the nucleus.
22664934 2012 Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach.
21269460 2011 Initial characterization of the human central proteome.
20877624 2010 Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
20635389 2011 Common alleles in candidate susceptibility genes associated with risk and development of epithelial ovarian cancer.
20213681 2010 Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system.
19270026 2009 Functional complementation studies identify candidate genes and common genetic variants associated with ovarian cancer survival.
17974005 2007 The full-ORF clone resource of the German cDNA Consortium.
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