Property Summary

NCBI Gene PubMed Count 11
Grant Count 3
Funding $385,290
PubMed Score 31.81
PubTator Score 2.79

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (7)

Disease log2 FC p
astrocytic glioma -1.400 0.015
ependymoma -1.300 0.038
atypical teratoid / rhabdoid tumor -1.100 0.000
glioblastoma -1.200 0.000
adult high grade glioma -1.100 0.004
non primary Sjogren syndrome sicca 1.100 0.025
pituitary cancer 1.100 0.000

Synonym

Accession Q9BRQ6 D6R9U0 D6RIB4 H8Y0Y7
Symbols CHCM1
Mic25
PPP1R23

Gene

Gene RIF (5)

PMID Text
26530328 mitochondria exhibited lower cristae density in CHCHD6-knockout cells. CHCHD6 directly interacted with Sam50.
22228767 CHCM1/CHCHD6, novel mitochondrial protein linked to regulation of mitofilin and mitochondrial cristae morphology.
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19240061 Observational study of gene-disease association. (HuGE Navigator)
17624330 anti-mitofilin mAb immunocaptures its target protein in association with six other proteins, metaxins 1 and 2, SAM50, CHCHD3, CHCHD6 and DnaJC11, respectively

AA Sequence

MGSTESSEGRRVSFGVDEEERVRVLQGVRLSENVVNRMKEPSSPPPAPTSSTFGLQDGNLRAPHKESTLP      1 - 70
RSGSSGGQQPSGMKEGVKRYEQEHAAIQDKLFQVAKREREAATKHSKASLPTGEGSISHEEQKSVRLARE     71 - 140
LESREAELRRRDTFYKEQLERIERKNAEMYKLSSEQFHEAASKMESTIKPRRVEPVCSGLQAQILHCYRD    141 - 210
RPHEVLLCSDLVKAYQRCVSAAHKG                                                 211 - 235
//

Publication (17)

PMID Year Title
26530328 2015 Mitofilin and CHCHD6 physically interact with Sam50 to sustain cristae structure.
25997101 2015 QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25781180 2015 Detailed analysis of the human mitochondrial contact site complex indicate a hierarchy of subunits.
24687277 2014 Uniform nomenclature for the mitochondrial contact site and cristae organizing system.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
22228767 2012 CHCM1/CHCHD6, novel mitochondrial protein linked to regulation of mitofilin and mitochondrial cristae morphology.
21269460 2011 Initial characterization of the human central proteome.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
19389623 2009 Docking motif-guided mapping of the interactome of protein phosphatase-1.
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