Property Summary

NCBI Gene PubMed Count 26
PubMed Score 16.11
PubTator Score 8.37

Knowledge Summary


No data available


  Disease Sources (1)

Disease Target Count P-value
diabetes mellitus 1663 0.00244940723388655
pancreatic ductal adenocarcinoma liver metastasis 1795 0.00579819879637366


  Differential Expression (2)

Disease log2 FC p
pancreatic ductal adenocarcinoma liver m... -1.142 0.006
diabetes mellitus -1.200 0.002


Accession Q9BRG1 B2R581 hVps25
Symbols DERP9



2ZME   3CUQ   3HTU  

  Ortholog (9)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid
C. elegans OMA EggNOG Inparanoid
Fruitfly OMA Inparanoid
S.cerevisiae OMA EggNOG Inparanoid

Gene RIF (8)

26268989 HIV-1 release (as measured by CA-p24 levels) from cells involves VPS25 (EAP20)
26268989 shRNA knockdown of VPS25 (ESCRT-II component) impairs HIV-1 CA-p24 production when using wild type (HIV-1 LAI) and VSV-pseudotyped virus; HIV replication is enhanced by VPS25
23305486 HIV-1 release (as measured by CA-p24 levels) from cells involves VPS25 (EAP20)
21543492 HIV-1 release (as measured by CA-p24 levels) from cells involves VPS25 (EAP20)
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19913121 Observational study of gene-disease association. (HuGE Navigator)
19686684 Results describe the mapping of multivesicular bodies with the second winged helix domain of human ESCRT-II subunit VPS25 and the first helix of ESCRT-III subunit VPS20.
16371348 mammalian ESCRTII is made up of hVps25p, hVps22p, and hVps36p and may be redundant, cargo-specific, or not required for protein sorting at the multivesicular body

AA Sequence

FHGLDEATLLRALQALQQEHKAEIITVSDGRGVKFF                                      141 - 176

Text Mined References (31)

PMID Year Title
25416956 2014 A proteome-scale map of the human interactome network.
23533145 2013 In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
21516116 2011 Next-generation sequencing to generate interactome datasets.
21269460 2011 Initial characterization of the human central proteome.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
20588296 2010 Membrane budding and scission by the ESCRT machinery: it's all in the neck.
19913121 2009 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
19686684 2009 Structure and function of the ESCRT-II-III interface in multivesicular body biogenesis.
19056867 2009 Large-scale proteomics and phosphoproteomics of urinary exosomes.