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Tbio
CLSTN3
Calsyntenin-3

Protein Summary
Description
May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266546
  • ENSP00000266546
  • ENSG00000139182

Symbol
  • CS3
  • KIAA0726
  • CSTN3
  • CDHR14
  • alcbeta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.82
histone modification site profile
0.79
cellular component
0.76
transcription factor
0.72
cell line
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.79   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 26   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.79   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 26   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0