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  6. Nuclear receptor-interacting protein 2

Tdark Nuclear receptor-interacting protein 2

Down-regulates transcriptional activation by nuclear receptors such as NR1F2.

 Comments

Property Summary

NCBI Gene PubMed Count 12
PubMed Score 0.63

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (1)

Disease Target Count P-value
posterior fossa group A ependymoma 1511 1.26577903200848E-6
atypical teratoid / rhabdoid tumor 4369 3.18031157926211E-5
psoriasis 6685 5.44771105694265E-4
glioblastoma 5572 0.00160936864329242
pilocytic astrocytoma 3086 0.00366397558270743
adult high grade glioma 2148 0.00391920699587259
colon cancer 1475 0.00750345262386311
sonic hedgehog group medulloblastoma 1482 0.0106082018587683
subependymal giant cell astrocytoma 2287 0.0138434621292008
medulloblastoma, large-cell 6234 0.0494028274070879

Expression

  Differential Expression (10)

Disease log2 FC p
psoriasis -1.500 0.001
glioblastoma -1.500 0.002
atypical teratoid / rhabdoid tumor -1.600 0.000
medulloblastoma, large-cell -1.300 0.049
colon cancer -1.100 0.008
adult high grade glioma -1.500 0.004
pilocytic astrocytoma -1.100 0.004
posterior fossa group A ependymoma -1.300 0.000
sonic hedgehog group medulloblastoma 2.000 0.011
subependymal giant cell astrocytoma -1.842 0.014

Synonym

Accession Q9BQI9 A2RRE3 B4DV61
Symbols

Gene

NRIP2

PANTHER Protein Class (3)

  Ortholog (8)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG
Pig OMA EggNOG
Opossum OMA EggNOG Inparanoid

 GO Function (1)

 GO Component (2)

 GO Process (2)

 Compartment GO Term (11)

 HCA RNA Cell Line (56)

See all...

Pathway (1)

 UniProt Keyword (6)

Gene RIF (1)

PMID Text
17075290 Observational study of gene-disease association. (HuGE Navigator)

AA Sequence 

MLFIFPLSLPWRPSCWKESCSTGQRQAGRSREDSVTPPPSSPWPTPPAGAMSTKQEARRDEGEARTRGQE      1 - 70
AQLRDRAHLSQQRRLKQATQFLHKDSADLLPLDSLKRLGTSKDLQPRSVIQRRLVEGNPNWLQGEPPRMQ     71 - 140
DLIHGQESRRKTSRTEIPALLVNCKCQDQLLRVAVDTGTQYNRISAGCLSRLGLEKRVLKASAGDLAPGP    141 - 210
PTQVEQLELQLGQETVVCSAQVVDAESPEFCLGLQTLLSLKCCIDLEHGVLRLKAPFSELPFLPLYQEPG    211 - 280
Q//

Text Mined References (13)

PMID Year Title
25416956 2014 A proteome-scale map of the human interactome network.
17075290 2006 Association of the RIP2 gene with childhood atopic asthma.
16541075 2006 The finished DNA sequence of human chromosome 12.
16381901 2006 The LIFEdb database in 2006.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15489336 2004 From ORFeome to biology: a functional genomics pipeline.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11256614 2000 Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.
More...