Tbio SLF1 SMC5-SMC6 complex localization factor protein 1

Protein Summary

Description

Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions (PubMed:25931565).

Uniprot Accession IDs

• Q9BQI6
• B4DMG4
• Q3B7K4
• Q6NSA5
• Q6PHW9
• Q9Y402

Gene Name

• SLF1

Ensembl ID

• ENST00000265140
• ENSP00000265140
• ENSG00000133302
• ENST00000508130
• ENSP00000424232

Symbol

• ANKRD32
• BRCTD1
• BRCTx
• BRCTD1
• ANKRD32

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.69   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 133   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.69   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0