Tclin VKORC1 Vitamin K epoxide reductase complex subunit 1

Protein Summary

Description

Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development. This gene encodes the catalytic subunit of the vitamin K epoxide reductase complex, which is responsible for the reduction of inactive vitamin K 2,3-epoxide to active vitamin K in the endoplasmic reticulum membrane. Vitamin K is a required co-factor for carboxylation of glutamic acid residues by vitamin K-dependent gamma-carboxylase in blood-clotting enzymes. Allelic variation in this gene is associated with vitamin k-dependent clotting factors combined deficiency of 2, and increased resistance or sensitivity to warfarin, an inhibitor of vitamin K epoxide reductase. Pseudogenes of this gene are located on chromosomes 1 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

Uniprot Accession IDs

• Q9BQB6
• A6NIQ6
• B2R4Z6
• Q6UX90
• Q7Z2R4

Gene Name

• VKORC1

Ensembl ID

• ENST00000319788
• ENSP00000326135
• ENSG00000167397
• ENST00000354895
• ENSP00000346969
• ENST00000394975
• ENSP00000378426

Symbol

• VKOR
• VKOR
• MST134
• MST576
• VKCFD2
• EDTP308

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.99
biological term	0.98
transcription factor perturbation	0.94
transcription factor binding site profile	0.84
virus perturbation	0.83

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Vitamin K Epoxide Reductase Complex Subunit 1

DTO Classes

Protein / Enzyme / Oxidoreductase / Vitamin K Epoxide Reductase Complex Subunit 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 833.34   (req: < 5)

Gene RIFs: 337   (req: <= 3)

Antibodies: 105   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 833.34   (req: >= 5)

Gene RIFs: 337   (req: > 3)

Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5