Tbio TREX2 Three prime repair exonuclease 2

Protein Summary

Description

Exonuclease with a preference for double-stranded DNA with mismatched 3' termini. May play a role in DNA repair. This gene encodes a nuclear protein with 3' to 5' exonuclease activity. The encoded protein participates in double-stranded DNA break repair, and may interact with DNA polymerase delta. [provided by RefSeq, Nov 2012]

Uniprot Accession IDs

• Q9BQ50
• Q45F08
• Q9UN77

Gene Name

• TREX2

Ensembl ID

• ENST00000330912
• ENSP00000333441
• ENSG00000183479
• ENST00000334497
• ENSP00000334993
• ENST00000338525
• ENSP00000345218
• ENST00000370212
• ENSP00000359231
• ENST00000370231
• ENSP00000359251
• ENST00000370232
• ENSP00000359252
• ENST00000393862
• ENSP00000377442

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.86
molecular function	0.84
disease perturbation	0.79
cell type or tissue	0.67
co-expressed gene	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.5   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 116   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.5   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0