Tbio DHRS9 Dehydrogenase/reductase SDR family member 9

Protein Summary

Description

3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. May play a role in the biosynthesis of retinoic acid from retinaldehyde, but seems to have low activity with retinoids. Can utilize both NADH and NADPH. This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. This protein demonstrates oxidoreductase activity toward hydroxysteroids and is able to convert 3-alpha-tetrahydroprogesterone to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone in the cytoplasm, and may additionally function as a transcriptional repressor in the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Uniprot Accession IDs

• Q9BPW9
• B7Z416
• D3DPC1
• Q5RKX1
• Q9NRA9
• Q9NRB0

Gene Name

• DHRS9

Ensembl ID

• ENST00000357546
• ENSP00000350154
• ENSG00000073737
• ENST00000412271
• ENSP00000407747
• ENST00000421653
• ENSP00000388066
• ENST00000428522
• ENSP00000388564
• ENST00000432060
• ENSP00000389241
• ENST00000436483
• ENSP00000407167
• ENST00000602501
• ENSP00000473337

Symbol

• RDH15
• SDR9C4
• RDHL
• RDH15
• RDH-E2
• RDHTBE
• SDR9C4
• RDH-TBE
• RETSDR8
• 3ALPHA-HSD
• 3-alpha-HSD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.91
virus perturbation	0.83
cellular component	0.67
transcription factor	0.61
gene perturbation	0.6

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Dehydrogenase/reductase Sdr Family Member 9

Protein / Oxidoreductase / Dehydrogenase / Dehydrogenase/reductase Sdr Family Member 9

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / Dehydrogenase/reductase Sdr Family Member 9

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 416.42   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 217   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 416.42   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 217   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0