Tchem P2RY13 P2Y purinoceptor 13

Protein Summary

Description

Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system. The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is activated by ADP. [provided by RefSeq, Sep 2008]

Uniprot Accession IDs

• Q9BPV8
• B2R827
• Q05C50
• Q6DKN4
• Q8IUT5
• Q8TDU7
• Q9BY61
• P2Y13

Gene Name

• P2RY13

Ensembl ID

• ENST00000325602
• ENSP00000320376
• ENSG00000181631

Symbol

• GPR86
• GPR94
• GPCR1
• GPR86
• GPR94
• P2Y13
• SP174
• FKSG77

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.7
gene perturbation	0.65
tissue sample	0.59
ligand (chemical)	0.56
tissue	0.55

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / P2y Purinoceptor 13

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Purinoceptor / P2y Receptor / P2y Purinoceptor 13

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.95   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 339   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.95   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 339   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 12

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3