| Tdark | Histone H2B type 1-N |
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
Comments
Property Summary
| NCBI Gene PubMed Count | 22 |
| Grant Count | 4 |
| R01 Count | 4 |
| Funding | $684,000 |
| PubMed Score | 30.22 |
| PubTator Score | 1.00 |
| PMID | Text |
|---|---|
| 24256813 | Hypomethylation of ATG4A and HIST1H2BN in ovarian tumor-initiating cells predicts a poor prognosis for ovarian cancer patients. |
| 22174317 | HIV-1 Rev interacting protein, histone cluster 1, H2bn (HIST1H2BN), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells |
| 14657027 | HIV-1 Rev interacting protein, histone cluster 1, H2bn (HIST1H2BN), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells |
| 11689053 | HIV-1 Rev interacting protein, histone cluster 1, H2bn (HIST1H2BN), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells |
| 11080476 | HIV-1 Rev interacting protein, histone cluster 1, H2bn (HIST1H2BN), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells |
| 9566873 | HIV-1 Rev interacting protein, histone cluster 1, H2bn (HIST1H2BN), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells |
| PMID | Year | Title |
|---|---|---|
| 24256813 | 2014 | Hypomethylation signature of tumor-initiating cells predicts poor prognosis of ovarian cancer patients. |
| 23824326 | 2013 | USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing. |
| 21925322 | 2011 | Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. |
| 21726816 | 2011 | The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation. |
| 21630459 | 2011 | Proteomic characterization of the human sperm nucleus. |
| 20458337 | MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. | |
| 16916647 | 2006 | Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. |
| 16713563 | 2006 | Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. |
| 16627869 | 2006 | Quantitative proteomic analysis of post-translational modifications of human histones. |
| 16319397 | 2006 | Characterization of histone H2A and H2B variants and their post-translational modifications by mass spectrometry. |
| More... |
