Property Summary

NCBI Gene PubMed Count 64
Grant Count 215
R01 Count 125
Funding $27,983,993.75
PubMed Score 116.00
PubTator Score 90.94

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (10)

Disease log2 FC p
Multiple myeloma 1.193 0.012
glioblastoma 1.400 0.007
medulloblastoma, large-cell -2.000 0.000
lung cancer -1.200 0.005
group 4 medulloblastoma -1.300 0.000
posterior fossa group B ependymoma 1.200 0.000
subependymal giant cell astrocytoma 1.244 0.045
invasive ductal carcinoma 1.073 0.004
nasopharyngeal carcinoma -1.200 0.000
ovarian cancer 2.200 0.000

Synonym

Accession Q99828 B5BU40 H6WJF3 O00693 O00735 Q6IB49 Q96J54 Q99971 CIB
Symbols CIB
CIBP
KIP1
PRKDCIP
SIP2-28

Gene

PDB

1DGU   1DGV   1XO5   1Y1A   2L4H   2L4I   2LM5  

Gene RIF (36)

PMID Text
26105795 a large subset of TNBCs depend on CIB1 for cell survival and tumor growth, independent of CIB1 expression levels.
25012820 KIP binding to TRF2 enhances the telomere-binding activity of TRF2, suggesting that KIP acts as a positive regulator of TRF2 function.
24585405 High serum CIB1 levels are associated with pancreatic cancer.s
24550731 these studies suggested that Kaposi's sarcoma-associated herpesvirus utilizes CIB1 as one of the key molecule(s) to coordinate and sustain the EphA2 mediated signaling involved in its entry
24464679 mRNA and protein expression levels of CIB1 were decreased in the oligoasthenozoospermia patients.CIB1 may be involved in the pathogenesis of oligoasthenozoospermia by the CDK1 signaling pathway.
24011356 we present data that show that CIB1 binds to seven additional alpha-integrin CT peptides, bringing the total number of alpha-integrins that can associate with CIB1 to eight.
23503467 CIB1a is a novel mediator of PKD2-driven carcinogenesis.
22964641 Results indicate that CIB1 is uniquely positioned to regulate PI3K/AKT and MEK/ERK signaling and that simultaneous disruption of these pathways synergistically induces a nuclear GAPDH-dependent cell death.
22547769 The CIB1 and calcineurin expression was increased in AF atrial tissue and was related to the type of AF. This finding suggests that CIB1 may be involved in the pathogenesis of AF in VHD patients.
21857112 CIB1 may be used as a novel prognostic factor and possibly an attractive therapeutic target for hepatocellular carcinoma.
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AA Sequence

MGGSGSRLSKELLAEYQDLTFLTKQEILLAHRRFCELLPQEQRSVESSLRAQVPFEQILSLPELKANPFK      1 - 70
ERICRVFSTSPAKDSLSFEDFLDLLSVFSDTATPDIKSHYAFRIFDFDDDGTLNREDLSRLVNCLTGEGE     71 - 140
DTRLSASEMKQLIDNILEESDIDRDGTINLSEFQHVISRSPDFASSFKIVL                       141 - 191
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Text Mined References (71)

PMID Year Title
26105795 2015 CIB1 depletion impairs cell survival and tumor growth in triple-negative breast cancer.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25012820 2014 DNA-PKcs-interacting protein KIP binding to TRF2 is required for the maintenance of functional telomeres.
24585405 2014 Profiling of autoantibodies in sera of pancreatic cancer patients.
24550731 2014 CIB1 synergizes with EphrinA2 to regulate Kaposi's sarcoma-associated herpesvirus macropinocytic entry in human microvascular dermal endothelial cells.
24464679 2014 Calcium- and integrin-binding protein-1 is down-regulated in the sperm of patients with oligoasthenozoospermia : CIB1 expression in patients with oligoasthenozoospermia.
24011356 2013 Identification of novel integrin binding partners for calcium and integrin binding protein 1 (CIB1): structural and thermodynamic basis of CIB1 promiscuity.
23533145 2013 In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
23503467 2014 A novel splice variant of calcium and integrin-binding protein 1 mediates protein kinase D2-stimulated tumour growth by regulating angiogenesis.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
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