Tchem MAP3K3 Mitogen-activated protein kinase kinase kinase 3

Protein Summary

Description

Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q99759
• B2RCW2
• D3DU15
• Q5BKZ6
• Q8N3I9

Gene Name

• MAP3K3

Ensembl ID

• ENST00000361357
• ENSP00000354927
• ENSG00000198909
• ENST00000361733
• ENSP00000354485
• ENST00000579585
• ENSP00000461988

Symbol

• MAPKKK3
• MEKK3
• MEKK3
• MAPKKK3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
hub protein	1
drug perturbation	0.99
molecular function	0.99
small molecule	0.95

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Ste Group / Ste11 Family / Mitogen-activated Protein Kinase Kinase Kinase 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.37   (req: < 5)

Gene RIFs: 45   (req: <= 3)

Antibodies: 212   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.37   (req: >= 5)

Gene RIFs: 45   (req: > 3)

Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0