NAP1L4
Nucleosome assembly protein 1-like 4
Protein Summary
Acts as histone chaperone in nucleosome assembly. This gene encodes a member of the nucleosome assembly protein (NAP) family which can interact with both core and linker histones. It can shuttle between the cytoplasm and nucleus, suggesting a role as a histone chaperone. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. [provided by RefSeq, Jul 2008]
- ENST00000380542
- ENSP00000369915
- ENSG00000205531
- ENST00000526115
- ENSP00000436397
- ENST00000616696
- ENSP00000478654
- ENSG00000273562
- ENST00000619695
- ENSP00000483728
- ENST00000620138
- ENSP00000481412
- ENST00000632791
- ENSP00000487984
- NAP2
- NAP2
- NAP2L
- hNAP2
- NAP1L4b
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.98 | ||
virus perturbation | 0.92 | ||
co-expressed gene | 0.91 | ||
disease perturbation | 0.87 | ||
transcription factor perturbation | 0.8 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12.22 (req: < 5)
Gene RIFs: 11 (req: <= 3)
Antibodies: 64 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12.22 (req: >= 5)
Gene RIFs: 11 (req: > 3)
Antibodies: 64 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0