Property Summary

NCBI Gene PubMed Count 57
PubMed Score 100.60
PubTator Score 50.89

Knowledge Summary


No data available


  Disease Sources (5)

Disease Target Count
IGA Glomerulonephritis 454
Disease Target Count P-value
lung carcinoma 2844 3.33159952097407E-32
malignant mesothelioma 3163 1.1606252631843E-9
posterior fossa group A ependymoma 1511 1.7531704745011E-7
pilocytic astrocytoma 3086 7.17488413773525E-7
ovarian cancer 8492 1.14664263355449E-6
pituitary cancer 1972 5.06132962776843E-6
lung cancer 4473 1.83080733902469E-4
primitive neuroectodermal tumor 3031 3.89944840327759E-4
atypical teratoid / rhabdoid tumor 4369 4.64689132213292E-4
dermatomyositis 967 8.92927573829729E-4
pancreatic cancer 2300 0.00145232681326352
pediatric high grade glioma 2712 0.00169256804182033
glioblastoma 5572 0.00257793998839536
Down syndrome 548 0.00264402899165897
osteosarcoma 7933 0.00485874431530816
primary pancreatic ductal adenocarcinoma 1271 0.00533760328290444
medulloblastoma, large-cell 6234 0.0112811030751885
esophageal adenocarcinoma 737 0.0361585797852543
Multiple myeloma 1328 0.0485484634116435
Disease Target Count
Charcot-Marie-Tooth disease 1C 1


  Differential Expression (19)

Disease log2 FC p
Multiple myeloma 1.132 0.049
malignant mesothelioma 5.000 0.000
esophageal adenocarcinoma 1.100 0.036
osteosarcoma 1.361 0.005
posterior fossa group A ependymoma 1.500 0.000
glioblastoma 2.100 0.003
atypical teratoid / rhabdoid tumor 1.500 0.000
medulloblastoma, large-cell -1.100 0.011
primitive neuroectodermal tumor 1.800 0.000
primary pancreatic ductal adenocarcinoma 1.308 0.005
lung cancer -3.000 0.000
pediatric high grade glioma 1.200 0.002
pilocytic astrocytoma 1.800 0.000
lung carcinoma -1.800 0.000
ovarian cancer -2.200 0.000
pituitary cancer -1.900 0.000
Down syndrome 1.100 0.003
pancreatic cancer 1.500 0.001
dermatomyositis 1.100 0.001


Accession Q99732 D3DUG1 G5E9K0 Q05DW0 Q9C0L6 LPS-induced TNF-alpha factor
Symbols PIG7


PANTHER Protein Class (1)

  Ortholog (10)

Species Source
Chimp OMA EggNOG
Macaque EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG
Platypus OMA EggNOG Inparanoid
Chicken OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid

Gene RIF (33)

26716897 PIG7 promotes leukemia cell chemosensitivity via lysosomal membrane permeabilization.
26573228 Suggest LITAF as regulatory of pro-inflammatory and pro-fibrogenic pattern in non-alcoholic fatty liver disease.
26324337 LITAF may serve as a switch in the balance between classical and alternative activation in tumor-associated inflammation. (Review)
25342198 Study shows that the I92V LITAF sequence variant would be a good candidate for a biomarker in the case of the CMT1A/HNPP disorders.
25058650 Results show that LITAF mutants in Charcot-Marie-Tooth 1C have an altered intracellular localization. They localize either completely or partially in the mitochondria depending on the mutation site. This can explain the different severity of the disease.
24880540 The results of this study findings confirm that the genetic analysis of LITAF/SIMPLE should be considered for the diagnostic flow-chart of CMT1 patient, especially when nerve conduction studies show the presence of conduction blocks.
24668782 Early-onset hereditary neuropathy with liability to pressure palsy (HNPP) was associated frequently with isoleucine92valine LITAF polymorphism.
23795761 LITAF, a BCL6 target gene, regulates autophagy in mature B-cell lymphomas.
23576546 Mutation of SIMPLE (Litaf) in Charcot-Marie-Tooth 1C disease alters production of exosomes.
23333304 HIV-1 Vif upregulates the expression of lipopolysaccharide-induced TNF factor (LITAF) in Vif-expression T cells

AA Sequence

LQDVDHYCPNCRALLGTYKRL                                                     141 - 161

Text Mined References (57)

PMID Year Title
26716897 2016 PIG7 promotes leukemia cell chemosensitivity via lysosomal membrane permeabilization.
26573228 2015 LPS-induced TNF-? factor mediates pro-inflammatory and pro-fibrogenic pattern in non-alcoholic fatty liver disease.
26324337 2015 Lipopolysaccharide-induced tumor necrosis factor-? factor enhances inflammation and is associated with cancer (Review).
25416956 2014 A proteome-scale map of the human interactome network.
25342198 2015 The LITAF/SIMPLE I92V sequence variant results in an earlier age of onset of CMT1A/HNPP diseases.
25058650 2014 LITAF mutations associated with Charcot-Marie-Tooth disease 1C show mislocalization from the late endosome/lysosome to the mitochondria.
24952745 2014 Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
24880540 2014 A novel LITAF/SIMPLE mutation within a family with a demyelinating form of Charcot-Marie-Tooth disease.
24668782 2014 Clinical, electrophysiological, and molecular findings in early onset hereditary neuropathy with liability to pressure palsy.
24554482 2014 Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384.