Tclin | Sigma non-opioid intracellular receptor 1 |
This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Mutations in this gene has been associated with juvenile amyotrophic lateral sclerosis 16. Alternative splicing of this gene results in transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2013]
Comments
Property Summary
Ligand Count | 1,855 |
NCBI Gene PubMed Count | 88 |
PubMed Score | 209.97 |
PubTator Score | 84.16 |
Disease | Target Count |
---|---|
General anesthesia | 53 |
Labor pain | 4 |
Local anesthesia | 40 |
Pain | 103 |
Disease | Target Count | P-value |
---|---|---|
ovarian cancer | 8520 | 3.9e-06 |
lung cancer | 4740 | 2.3e-03 |
medulloblastoma, large-cell | 6241 | 2.5e-03 |
colon cancer | 1478 | 3.0e-03 |
pancreatic ductal adenocarcinoma liver metastasis | 1962 | 3.7e-02 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Neurodegenerative disease | 414 | 0.0 | 4.0 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Lateral sclerosis | 15 | 3.042 | 1.5 |
Disease | Target Count |
---|---|
Distal hereditary motor neuropathy, Jerash type | 1 |
Juvenile amyotrophic lateral sclerosis | 4 |
Disease | log2 FC | p |
---|---|---|
colon cancer | 1.600 | 3.0e-03 |
lung cancer | 1.900 | 2.3e-03 |
medulloblastoma, large-cell | 1.300 | 2.5e-03 |
ovarian cancer | 1.400 | 3.9e-06 |
pancreatic ductal adenocarcinoma liver m... | -1.255 | 3.7e-02 |
Species | Source | Disease |
---|---|---|
Inparanoid OMA EggNOG | ||
Inparanoid EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG |
pentazocine
pEC50 8.76
cisapride
pIC50 6.00
methysergide
pIC50 6.04
buflomedil
pKi 6.04
tetracaine
pKi 6.15
dexchlorpheniramine
pKi 6.16
raloxifene
pIC50 6.17
mepyramine
pKi 6.18
loperamide
pIC50 6.20
doxepin
pIC50 6.20
terbinafine
pIC50 6.25
phentolamine
pIC50 6.26
buspirone
pIC50 6.30
dimenhydrinate
pKi 6.31
chlorpromazine
pIC50 6.35
ticlopidine
pIC50 6.37
thioridazine
pIC50 6.44
mosapride
pIC50 6.52
promethazine
pIC50 6.54
promazine
pIC50 6.57
CHEMBL6224
pIC50 6.00
CHEMBL275528
pIC50 6.00
CHEMBL328986
pIC50 6.00
CHEMBL1089752
pIC50 6.00
CHEMBL557002
pIC50 6.01
CHEMBL285203
pIC50 6.01
CHEMBL336706
pIC50 6.02
CHEMBL320435
pIC50 6.02
CHEMBL2374421
pIC50 6.02
CHEMBL78356
pIC50 6.02
CHEMBL553745
pIC50 6.02
CHEMBL267930
pIC50 6.02
CHEMBL142617
pIC50 6.02
CHEMBL716
pKi 6.02
CHEMBL435046
pKi 6.03
CHEMBL419161
pKi 6.03
CHEMBL607156
pIC50 6.03
CHEMBL2391379
pIC50 6.03
CHEMBL296419
pKi 6.03
CHEMBL2105667
pKi 6.03