Tclin SIGMAR1 Sigma non-opioid intracellular receptor 1

Protein Summary

Description

Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration (PubMed:16472803, PubMed:9341151). Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria. Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112 (By similarity). This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Mutations in this gene has been associated with juvenile amyotrophic lateral sclerosis 16. Alternative splicing of this gene results in transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2013]

Uniprot Accession IDs

• Q99720
• D3DRM7
• O00673
• O00725
• Q0Z9W6
• Q153Z1
• Q2TSD1
• Q53GN2
• Q7Z653
• Q8N7H3
• Q9NYX0

Gene Name

• SIGMAR1

Ensembl ID

• ENST00000277010
• ENSP00000277010
• ENSG00000147955
• ENST00000353468
• ENSP00000434453
• ENST00000477726
• ENSP00000420022

Symbol

• OPRS1
• SRBP
• SRBP
• ALS16
• DSMA2
• OPRS1
• SR-BP
• SIG-1R
• SR-BP1
• sigma1R
• hSigmaR1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.87
cellular component	0.86
transcription factor perturbation	0.8
disease perturbation	0.74
virus perturbation	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 460.63   (req: < 5)

Gene RIFs: 113   (req: <= 3)

Antibodies: 215   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 460.63   (req: >= 5)

Gene RIFs: 113   (req: > 3)

Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2145

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 62