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Tclin
SIGMAR1
Sigma non-opioid intracellular receptor 1

Protein Summary
Description
Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration (PubMed:16472803, PubMed:9341151). Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria. Plays a role in protecting cells against oxidative stress-induc ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000277010
  • ENSP00000277010
  • ENSG00000147955
  • ENST00000353468
  • ENSP00000434453
  • ENST00000477726
  • ENSP00000420022

Symbol
  • OPRS1
  • SRBP
  • SRBP
  • ALS16
  • DSMA2
  • OPRS1
  • SR-BP
  • SIG-1R
  • SR-BP1
  • sigma1R
  • hSigmaR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.87
cellular component
0.86
transcription factor perturbation
0.8
disease perturbation
0.74
virus perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 460.63   (req: < 5)
Gene RIFs: 113   (req: <= 3)
Antibodies: 215   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 460.63   (req: >= 5)
Gene RIFs: 113   (req: > 3)
Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2145
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 62