Property Summary

NCBI Gene PubMed Count 75
Grant Count 66
R01 Count 33
Funding $5,447,162.48
PubMed Score 41.46
PubTator Score 54.90

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (3)

Disease log2 FC p
osteosarcoma -2.147 0.000
glioblastoma 1.100 0.000
spina bifida 1.149 0.026

Synonym

Accession Q99704 O43204 Q53TY2 Q9UHG6
Symbols pp62
P62DOK

Gene

PDB

2V76  

Gene RIF (39)

PMID Text
27265473 DOK3 expression was not altered much in HTLV-1-infected T cells.
27078152 Results indicate that hypermethylation of tumor suppressor protein RASSF1A and docking protein 1 (DOK1) contributes to hepatocarcinogenesis and is associated to clinicopathological characteristics.
26108885 Data show that residues Ser745 and Ser756 in the integrin beta2 tail, which are adjacent to the NxxF motif, are required for docking protein 1, docking protein 1, 62kDa (downstream of tyrosine kinase 1) (Dok1) interaction.
25252871 point mutations in DOK1 and DOK2 genes are detected with low frequency in chronic myelomonocytic leukemia but may have consequences for the function of the DOK2 PTB domain
25043303 results support a model in which Dok1 phosphorylation normally suppresses localized Ras pathway activity in Crk-transformed cells via recruitment and/or activation of RasGAP
24963146 Taken together, these results reveal that Dok1 and Dok2 proteins are involved in an intrinsic negative feedback loop downstream of natural killer-cell-activating receptors in mouse and human.
24809689 Deregulation of DOK1 gene expression by EBV and novel insights into the regulation of the DOK1 tumor suppressor in viral-related carcinogenesis.
24762811 A crucial role for DOK1 in the regulation of PDGF-BB-mediated tumour cell motility through a p130Cas-Rap1 signalling pathway.
24587391 Data implicate existence of alternate conformational states around the ligand binding pocket of the PTB domain of phosphoprotien Dok1 either in the native or in the near native conditions.
24523872 BRK has a role in targeting Dok1 for ubiquitin-mediated proteasomal degradation and in promoting cell proliferation and migration
More...

AA Sequence

MDGAVMEGPLFLQSQRFGTKRWRKTWAVLYPASPHGVARLEFFDHKGSSSGGGRGSSRRLDCKVIRLAEC      1 - 70
VSVAPVTVETPPEPGATAFRLDTAQRSHLLAADAPSSAAWVQTLCRNAFPKGSWTLAPTDNPPKLSALEM     71 - 140
LENSLYSPTWEGSQFWVTVQRTEAAERCGLHGSYVLRVEAERLTLLTVGAQSQILEPLLSWPYTLLRRYG    141 - 210
RDKVMFSFEAGRRCPSGPGTFTFQTAQGNDIFQAVETAIHRQKAQGKAGQGHDVLRADSHEGEVAEGKLP    211 - 280
SPPGPQELLDSPPALYAEPLDSLRIAPCPSQDSLYSDPLDSTSAQAGEGVQRKKPLYWDLYEHAQQQLLK    281 - 350
AKLTDPKEDPIYDEPEGLAPVPPQGLYDLPREPKDAWWCQARVKEEGYELPYNPATDDYAVPPPRSTKPL    351 - 420
LAPKPQGPAFPEPGTATGSGIKSHNSALYSQVQKSGASGSWDCGLSRVGTDKTGVKSEGST             421 - 481
//

Text Mined References (80)

PMID Year Title
27265473 2016 Expression of DOK1, 2, and 3 genes in HTLV-1-infected T cells.
27078152 2016 RASSF1A and DOK1 Promoter Methylation Levels in Hepatocellular Carcinoma, Cirrhotic and Non-Cirrhotic Liver, and Correlation with Liver Cancer in Brazilian Patients.
26108885 2015 An Alternative Phosphorylation Switch in Integrin??2 (CD18) Tail for Dok1 Binding.
25252871 2015 Mutational analysis of the DOK2 haploinsufficient tumor suppressor gene in chronic myelomonocytic leukemia (CMML).
25043303 2015 Phosphorylation of Dok1 by Abl family kinases inhibits CrkI transforming activity.
24963146 2014 Dok1 and Dok2 proteins regulate natural killer cell development and function.
24809689 2014 Epstein-Barr virus down-regulates tumor suppressor DOK1 expression.
24762811 2014 A crucial role for DOK1 in PDGF-BB-stimulated glioma cell invasion through p130Cas and Rap1 signalling.
24587391 2014 NMR characterization of the near native and unfolded states of the PTB domain of Dok1: alternate conformations and residual clusters.
24523872 2014 BRK targets Dok1 for ubiquitin-mediated proteasomal degradation to promote cell proliferation and migration.
More...