Tbio GPR22 G-protein coupled receptor 22

Protein Summary

Description

Orphan G-protein coupled receptor. Seems to act through a G(i)/G(o) mediated pathway (PubMed:18539757). May be involved in ciliogenesis (By similarity). This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q99680
• A4D0R8
• O14554

Gene Name

• GPR22

Ensembl ID

• ENST00000304402
• ENSP00000302676
• ENSG00000172209
• ENST00000639742
• ENSP00000492841
• ENSG00000283812

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.6
kinase perturbation	0.54
disease perturbation	0.49
cell type or tissue	0.48
small molecule perturbation	0.44

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / G-protein Coupled Receptor 22

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Purinoceptor / Probable G-protein Coupled Receptor 22

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.78   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 270   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.78   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 270   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0