Tdark | Probable G-protein coupled receptor 22 |
Orphan receptor.
This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein. [provided by RefSeq, Jul 2008]
This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein. [provided by RefSeq, Jul 2008]
Comments
Disease | Target Count | P-value |
---|---|---|
ependymoma | 2514 | 8.49867009280963E-16 |
medulloblastoma | 1524 | 1.73968836495372E-14 |
atypical teratoid / rhabdoid tumor | 4369 | 3.52635973027606E-11 |
pilocytic astrocytoma | 3086 | 2.89279843999574E-7 |
glioblastoma | 5572 | 1.88153950932086E-6 |
permanent atrial fibrillation | 44 | 3.31079178655435E-6 |
primitive neuroectodermal tumor | 3031 | 9.0533210125846E-5 |
medulloblastoma, large-cell | 6234 | 2.90917640841055E-4 |
astrocytic glioma | 2241 | 9.55229819021224E-4 |
oligodendroglioma | 2849 | 0.0017451772937286 |
adult high grade glioma | 2148 | 0.00410675354618182 |
lung cancer | 4473 | 0.0228709742753605 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Osteoarthritis | 96 | 3.173 | 1.6 |
Disease | log2 FC | p |
---|---|---|
astrocytic glioma | -3.100 | 0.001 |
ependymoma | -3.600 | 0.000 |
oligodendroglioma | -3.000 | 0.002 |
permanent atrial fibrillation | -1.100 | 0.000 |
glioblastoma | -4.200 | 0.000 |
medulloblastoma | -4.700 | 0.000 |
atypical teratoid / rhabdoid tumor | -4.500 | 0.000 |
medulloblastoma, large-cell | -4.600 | 0.000 |
primitive neuroectodermal tumor | -4.200 | 0.000 |
lung cancer | 1.100 | 0.023 |
adult high grade glioma | -3.200 | 0.004 |
pilocytic astrocytoma | -3.600 | 0.000 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Macaque | OMA EggNOG Inparanoid |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA EggNOG Inparanoid |
Dog | OMA EggNOG Inparanoid |
Cow | OMA EggNOG Inparanoid |
Pig | OMA EggNOG Inparanoid |
Opossum | OMA EggNOG Inparanoid |
Platypus | OMA EggNOG |
Chicken | OMA EggNOG Inparanoid |
Anole lizard | OMA EggNOG Inparanoid |
Xenopus | OMA EggNOG |
Bryan Roth | functional assay |
Jing-Ruey Yeh | gRNA validated for zebrafish model, zebrafish mutant available |
Steve Finkbeiner | Neuron specific phenotypes being screened |
MCFSPILEINMQSESNITVRDDIDDINTNMYQPLSYPLSFQVSLTGFLMLEIVLGLGSNLTVLVLYCMKS 1 - 70 NLINSVSNIITMNLHVLDVIICVGCIPLTIVILLLSLESNTALICCFHEACVSFASVSTAINVFAITLDR 71 - 140 YDISVKPANRILTMGRAVMLMISIWIFSFFSFLIPFIEVNFFSLQSGNTWENKTLLCVSTNEYYTELGMY 141 - 210 YHLLVQIPIFFFTVVVMLITYTKILQALNIRIGTRFSTGQKKKARKKKTISLTTQHEATDMSQSSGGRNV 211 - 280 VFGVRTSVSVIIALRRAVKRHRERRERQKRVFRMSLLIISTFLLCWTPISVLNTTILCLGPSDLLVKLRL 281 - 350 CFLVMAYGTTIFHPLLYAFTRQKFQKVLKSKMKKRVVSIVEADPLPNNAVIHNSWIDPKRNKKITFEDSE 351 - 420 IREKCLVPQVVTD 421 - 433 //
PMID | Year | Title |
---|---|---|
21068099 | 2011 | Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. |
20112360 | 2010 | A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22. |
18539757 | 2008 | Myocardial expression, signaling, and function of GPR22: a protective role for an orphan G protein-coupled receptor. |
16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |
15955843 | 2005 | Effects of RNA degradation on gene expression analysis of human postmortem tissues. |
14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. |
12853948 | 2003 | The DNA sequence of human chromosome 7. |
12690205 | 2003 | Human chromosome 7: DNA sequence and biology. |
12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
9073069 | 1997 | Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes. |