Tdark GPR21 Probable G-protein coupled receptor 21

Protein Summary

Description

Orphan receptor. This gene encodes a member of the G-protein-coupled receptor 1 family. G-protein coupled receptors are membrane proteins which activate signaling cascades as a response to extracellular stress. The encoded protein activates a Gq signal transduction pathway which mobilizes calcium. [provided by RefSeq, Nov 2012]

Uniprot Accession IDs

• Q99679
• B2R8W9
• Q6NXU2

Gene Name

• GPR21

Ensembl ID

• ENST00000373642
• ENSP00000362746
• ENSG00000188394

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.67
kinase perturbation	0.6
cell line	0.57
small molecule perturbation	0.54
tissue sample	0.53

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Purinoceptor / Probable G-protein Coupled Receptor 21

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.58   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 48   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.58   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 48   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0