Property Summary

NCBI Gene PubMed Count 34
PubMed Score 14.96
PubTator Score 92.39

Knowledge Summary


No data available


  Disease Sources (1)

Disease Target Count P-value
atypical teratoid / rhabdoid tumor 4369 8.54118721111752E-8
ovarian cancer 8492 3.04937096974073E-7
malignant mesothelioma 3163 5.21840354569264E-6
glioblastoma 5572 7.90119326504435E-6
osteosarcoma 7933 1.37146592472711E-5
medulloblastoma, large-cell 6234 1.67318954559409E-5
acute quadriplegic myopathy 1157 5.80083452699786E-5
medulloblastoma 1524 6.80357580118105E-5
lung cancer 4473 1.03526556884931E-4
pilocytic astrocytoma 3086 2.06292461697602E-4
Pick disease 1893 4.6107209739654E-4
adult high grade glioma 2148 0.0010735838302543
primitive neuroectodermal tumor 3031 0.0192259884246488
ependymoma 2514 0.0229137827473367
astrocytic glioma 2241 0.0231662675540692
oligodendroglioma 2849 0.0265531864209824
pancreatic cancer 2300 0.0285853484634913
Alzheimer's disease 644 0.0311142476904239


  Differential Expression (18)

Disease log2 FC p
malignant mesothelioma -1.100 0.000
astrocytic glioma -2.000 0.023
ependymoma -1.600 0.023
oligodendroglioma -1.300 0.027
osteosarcoma 2.641 0.000
glioblastoma -2.000 0.000
atypical teratoid / rhabdoid tumor -2.300 0.000
medulloblastoma -1.400 0.000
medulloblastoma, large-cell -1.900 0.000
primitive neuroectodermal tumor -1.100 0.019
acute quadriplegic myopathy 1.122 0.000
lung cancer 1.700 0.000
adult high grade glioma -1.500 0.001
pilocytic astrocytoma -1.200 0.000
Alzheimer's disease -1.200 0.031
Pick disease -1.200 0.000
ovarian cancer -1.600 0.000
pancreatic cancer 1.100 0.029


Accession Q99627 A8K1H6 Q53QS9 SGN8
Symbols COP9


PANTHER Protein Class (1)


4D10   4D18   4WSN  

  Ortholog (12)

Species Source
Macaque OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG
Zebrafish OMA EggNOG Inparanoid
Fruitfly OMA EggNOG Inparanoid

Gene RIF (8)

23689509 Data indicate that silencing of Csn8 caused an increased growth rate, whereas silencing of Csn5 impaired proliferation in HeLa cells.
22992343 miR-146a expression is up-regulated in a majority of gastric cancers where it targets CARD10 and COPS8, inhibiting GPCR-mediated activation of NF-kappaB.
22414063 proteomic-based approach can broaden our understanding of the functions of the CSN in contexts such as viral-host interactions or immune activation in their natural milieu
22190034 HIV-1 Vpr is identified to have a physical interaction with COP9 constitutive photomorphogenic homolog subunit 8 (COPS8; CSN8) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses
20399188 analysis of the COP9 signalosome and its common architecture with the 26S proteasome lid and eIF3
18424433 COP9/signalosome increases the efficiency of von Hippel-Lindau protein ubiquitin ligase-mediated hypoxia-inducible factor-alpha ubiquitination
17318178 The COP9 signalosome (CSN) controls NF-kappaB by deubiquitinylation of IkappaBalpha.
12732143 DDB2 and CSA are each integrated into nearly identical complexes via interaction with DDB1. Both complexes contain cullin 4A and Roc1 and display ubiquitin ligase activity. They also contain the COP9 signalosome (CSN)

AA Sequence


Text Mined References (41)

PMID Year Title
27173435 2016 An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
25416956 2014 A proteome-scale map of the human interactome network.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23689509 2013 COP9 signalosome subunit Csn8 is involved in maintaining proper duration of the G1 phase.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22992343 2012 microRNA-146a inhibits G protein-coupled receptor-mediated activation of NF-?B by targeting CARD10 and COPS8 in gastric cancer.
22414063 2012 Purification of the COP9 signalosome complex and binding partners from human T cells.
21269460 2011 Initial characterization of the human central proteome.
20399188 2010 Structural insights into the COP9 signalosome and its common architecture with the 26S proteasome lid and eIF3.