Tbio SEPHS2 Selenide, water dikinase 2

Protein Summary

Description

Synthesizes selenophosphate from selenide and ATP. This gene encodes an enzyme that catalyzes the production of monoselenophosphate (MSP) from selenide and ATP. MSP is the selenium donor required for synthesis of selenocysteine (Sec), which is co-translationally incorporated into selenoproteins at in-frame UGA codons that normally signal translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is itself a selenoprotein containing a Sec residue at its active site, suggesting the existence of an autoregulatory mechanism. It is preferentially expressed in tissues implicated in the synthesis of selenoproteins and in sites of blood cell development. A pseudogene for this locus has been identified on chromosome 5. [provided by RefSeq, May 2017]

Uniprot Accession IDs

• Q99611
• Q9BUQ2

Gene Name

• SEPHS2

Ensembl ID

• ENST00000478753
• ENSP00000418669
• ENSG00000179918

Symbol

• SPS2
• SPS2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.99
transcription factor binding site profile	0.92
disease perturbation	0.9
molecular function	0.88
transcription factor perturbation	0.74

Protein Classes

PANTHER Classes

Protein / Transferase / Selenide, Water Dikinase 2

DTO Classes

Protein / Enzyme / Transferase / Selenide, Water Dikinase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.44   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.44   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0