| Tbio | ETS-related transcription factor Elf-4 |
Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2 (By similarity). Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway.
The protein encoded by this gene is a transcriptional activator that binds and activates the promoters of the CSF2, IL3, IL8, and PRF1 genes. The encoded protein is involved in natural killer cell development and function, innate immunity, and induction of cell cycle arrest in naive CD8+ cells. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010]
The protein encoded by this gene is a transcriptional activator that binds and activates the promoters of the CSF2, IL3, IL8, and PRF1 genes. The encoded protein is involved in natural killer cell development and function, innate immunity, and induction of cell cycle arrest in naive CD8+ cells. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010]
Comments
| Disease | Target Count |
|---|---|
| X-linked agammaglobulinemia with growth hormone deficiency | 2 |
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 3.1e-19 |
| ependymoma | 4679 | 8.2e-08 |
| adrenocortical carcinoma | 1428 | 1.1e-06 |
| Breast cancer | 3578 | 3.5e-05 |
| pancreatic cancer | 2398 | 6.0e-05 |
| ovarian cancer | 8520 | 6.4e-05 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 3.4e-04 |
| glioblastoma | 5792 | 5.1e-04 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 1.9e-03 |
| adult high grade glioma | 3801 | 3.3e-03 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 6.1e-03 |
| lung cancer | 4740 | 1.3e-02 |
| active Crohn's disease | 922 | 1.4e-02 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 1.4e-02 |
| osteosarcoma | 7950 | 1.6e-02 |
| primitive neuroectodermal tumor | 3035 | 2.0e-02 |
| acute myeloid leukemia | 783 | 2.2e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Dental caries | 164 | 0.0 | 1.2 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Cataract 7 | 32 | 3.257 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| active Crohn's disease | -1.076 | 1.4e-02 |
| acute myeloid leukemia | 1.100 | 2.2e-02 |
| adrenocortical carcinoma | 1.806 | 1.1e-06 |
| adult high grade glioma | 1.200 | 3.3e-03 |
| Breast cancer | 1.100 | 3.5e-05 |
| ependymoma | 1.700 | 8.2e-08 |
| glioblastoma | 1.400 | 5.1e-04 |
| intraductal papillary-mucinous adenoma (... | 2.300 | 3.4e-04 |
| intraductal papillary-mucinous carcinoma... | 2.100 | 1.9e-03 |
| intraductal papillary-mucinous neoplasm ... | 2.400 | 6.1e-03 |
| lung cancer | -1.100 | 1.3e-02 |
| lung carcinoma | -1.100 | 3.1e-19 |
| osteosarcoma | -1.128 | 1.6e-02 |
| ovarian cancer | 2.000 | 6.4e-05 |
| pancreatic cancer | 1.300 | 6.0e-05 |
| pancreatic ductal adenocarcinoma liver m... | 1.101 | 1.4e-02 |
| primitive neuroectodermal tumor | 1.300 | 2.0e-02 |
MAITLQPSDLIFEFASNGMDDDIHQLEDPSVFPAVIVEQVPYPDLLHLYSGLELDDVHNGIITDGTLCMT 1 - 70 QDQILEGSFLLTDDNEATSHTMSTAEVLLNMESPSDILDEKQIFSTSEMLPDSDPAPAVTLPNYLFPASE 71 - 140 PDALNRAGDTSDQEGHSLEEKASREESAKKTGKSKKRIRKTKGNRSTSPVTDPSIPIRKKSKDGKGSTIY 141 - 210 LWEFLLALLQDRNTCPKYIKWTQREKGIFKLVDSKAVSKLWGKQKNKPDMNYETMGRALRYYYQRGILAK 211 - 280 VEGQRLVYQFKEMPKDLVVIEDEDESSEATAAPPQASTASVASASTTRRTSSRVSSRSAPQGKGSSSWEK 281 - 350 PKIQHVGLQPSASLELGPSLDEEIPTTSTMLVSPAEGQVKLTKAVSASSVPSNIHLGVAPVGSGSALTLQ 351 - 420 TIPLTTVLTNGPPASTTAPTQLVLQSVPAASTFKDTFTLQASFPLNASFQDSQVAAPGAPLILSGLPQLL 421 - 490 AGANRPTNPAPPTVTGAGPAGPSSQPPGTVIAAFIRTSGTTAAPRVKEGPLRSSSYVQGMVTGAPMEGLL 491 - 560 VPEETLRELLRDQAHLQPLPTQVVSRGSHNPSLLGNQTLSPPSRPTVGLTPVAELELSSGSGSLLMAEPS 561 - 630 VTTSGSLLTRSPTPAPFSPFNPTSLIKMEPHDI 631 - 663 //
