Tbio MNT Max-binding protein MNT

Protein Summary

Description

Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'. The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q99583
• A8K6D1
• D3DTI7
• Q1ED38

Gene Name

• MNT

Ensembl ID

• ENST00000174618
• ENSP00000174618
• ENSG00000070444

Symbol

• BHLHD3
• ROX
• ROX
• MAD6
• MXD6
• bHLHd3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.97
disease perturbation	0.93
molecular function	0.86
transcription factor	0.81
kinase perturbation	0.71

Protein Classes

PANTHER Classes

Protein / ... / Basic Helix-loop-helix Transcription Factor / Max-binding Protein Mnt

DTO Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / Max-binding Protein Mnt

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 160.04   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 126   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 160.04   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0