Property Summary

NCBI Gene PubMed Count 50
PubMed Score 140.38
PubTator Score 71.97

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count P-value
lung adenocarcinoma 2714 4.12550494398001E-14
non-small cell lung cancer 2798 6.30341030551717E-11
psoriasis 6685 4.41459239406785E-8
lung cancer 4473 3.89628161395993E-7
acute quadriplegic myopathy 1157 2.28533100372631E-6
atypical teratoid/rhabdoid tumor 1095 7.75849626876305E-6
ovarian cancer 8492 1.60685521391763E-4
osteosarcoma 7933 2.0441539063313E-4
ulcerative colitis 2087 6.04988393264355E-4
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00157014623185684
group 3 medulloblastoma 2254 0.0021902085930638
medulloblastoma, large-cell 6234 0.00417910560643549
ductal carcinoma in situ 1745 0.0070774156224584
primary pancreatic ductal adenocarcinoma 1271 0.0187493935323473
colon cancer 1475 0.0201294083442708
pancreatic cancer 2300 0.0229706626986792
X-linked cerebral adrenoleukodystrophy 115 0.0242994715681486
chronic rhinosinusitis 512 0.0318085420437123
non primary Sjogren syndrome sicca 840 0.0339384437998688
invasive ductal carcinoma 2950 0.0378866558156684
cystic fibrosis and chronic rhinosinusitis 213 0.0390899442658679
Disease Target Count Z-score Confidence
glucocorticoid-induced osteoporosis 3 3.319 1.7



Accession Q99576 Q5H9S3 Q5JRI9 Q6FIH6 Q8NAI1 Q8WVB9 Q9UBN5 Q9UG13
Symbols DIP


PANTHER Protein Class (1)

  Ortholog (6)

Species Source
Macaque OMA EggNOG
Mouse OMA Inparanoid
Rat OMA Inparanoid
Horse OMA Inparanoid
Platypus OMA Inparanoid
Zebrafish OMA Inparanoid

Gene RIF (35)

26612340 GILZ is a non-redundant regulator of B cell activity, with important potential clinical implications in systemic lupus erythematosus.
26384220 results reveal GILZ to be a new actor in apoptosis regulation in neutrophil-like cells involving JNK and Mcl-1.
25964494 our data suggest that GILZ is a key regulator of macrophage functions.
25168242 L-GILZ stabilizes p53 proteins by decreasing p53 ubiquitination and increasing MDM2 ubiquitination.
24993177 The N-terminal part of L-GILZ protein is responsible for Ras/L-GILZ protein-to-protein interaction, important for the control of proliferation rate of spermatogonia.
24747114 Data show a diminished expression of the anti-inflammatory mediator GILZ in the inflamed vasculature and indicate that GILZ downregulation requires the mRNA binding protein ZFP36.
24215840 PUVA directly stimulates GILZ expression.
23729444 Exogenous GILZ exerts inhibitory effects on endothelial cell adhesive function via a novel pathway involving modulation of NF-kappaB p65 DNA binding and MAPK activity.
23650723 Delta-sleep inducing peptide entrapment and release from polymer hydrogels based on modified polyvinyl alcohol in vitro
23573276 Inhibition of epithelial injury repair by dexamethasone is mediated in part by activation of GILZ.

AA Sequence


Text Mined References (56)

PMID Year Title
26612340 2016 Glucocorticoid-induced leucine zipper (GILZ) inhibits B cell activation in systemic lupus erythematosus.
26384220 2016 Glucocorticoid-Induced Leucine Zipper Is Expressed in Human Neutrophils and Promotes Apoptosis through Mcl-1 Down-Regulation.
25964494 2015 Glucocorticoid-induced leucine zipper: a critical factor in macrophage endotoxin tolerance.
25416956 2014 A proteome-scale map of the human interactome network.
25168242 2015 L-GILZ binds p53 and MDM2 and suppresses tumor growth through p53 activation in human cancer cells.
24993177 2014 Recombinant long-glucocorticoid-induced leucine zipper (L-GILZ) protein restores the control of proliferation in gilz KO spermatogonia.
24747114 2014 Downregulation of the glucocorticoid-induced leucine zipper (GILZ) promotes vascular inflammation.
24215840 2014 Activation of GILZ gene by photoactivated 8-methoxypsoralen: potential role of immunoregulatory dendritic cells in extracorporeal photochemotherapy.
23729444 2013 GILZ overexpression inhibits endothelial cell adhesive function through regulation of NF-?B and MAPK activity.
23650723 [Delta-sleep inducing peptide entrapment and release from polymer hydrogels based on modified polyvinyl alcohol in vitro].