S1PR3
Sphingosine 1-phosphate receptor 3
Protein Summary
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis. This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function. [provided by RefSeq, Jul 2008]
- ENST00000358157
- ENSP00000350878
- ENSG00000213694
- ENST00000375846
- ENSP00000365006
- EDG3
- EDG3
- LPB3
- S1P3
- EDG-3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.8 | ||
gene perturbation | 0.77 | ||
small molecule perturbation | 0.68 | ||
cell type or tissue | 0.66 | ||
disease | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 277.16 (req: < 5)
Gene RIFs: 64 (req: <= 3)
Antibodies: 511 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 277.16 (req: >= 5)
Gene RIFs: 64 (req: > 3)
Antibodies: 511 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 263
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 4