Tchem DDO D-aspartate oxidase

Protein Summary

Description

Selectively catalyzes the oxidative deamination of D-aspartate and its N-methylated derivative, N-methyl D-aspartate. The protein encoded by this gene is a peroxisomal flavoprotein that catalyzes the oxidative deamination of D-aspartate and N-methyl D-aspartate. Flavin adenine dinucleotide or 6-hydroxyflavin adenine dinucleotide can serve as the cofactor in this reaction. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2019]

Uniprot Accession IDs

• Q99489
• A8KAG4
• Q5JXM4
• Q5JXM5
• Q5JXM6
• Q8N552
• DASOX

Gene Name

• DDO

Ensembl ID

• ENST00000368923
• ENSP00000357919
• ENSG00000203797
• ENST00000368924
• ENSP00000357920

Symbol

• DASOX
• DDO-1
• DDO-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.68
virus perturbation	0.59
tissue	0.54
histone modification site profile	0.52
gene perturbation	0.47

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.68   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 212   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.68   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0