Property Summary

NCBI Gene PubMed Count 18
PubMed Score 10.65
PubTator Score 5.17

Knowledge Summary


No data available


  Disease Sources (1)

Disease Target Count P-value
breast carcinoma 1614 1.06833516372163E-5
ovarian cancer 8492 2.58173278188398E-5
Multiple myeloma 1328 1.01175541114745E-4
invasive ductal carcinoma 2950 8.26686520086578E-4
diabetes mellitus 1663 0.00174083014961144
Waldenstrons macroglobulinemia 765 0.00437309328066801
acute myeloid leukemia 785 0.0297960332458489
Subcutaneous panniculitis-like T-cell lymphoma 16 0.0299252390802335
astrocytic glioma 2241 0.0411121981835193


  Differential Expression (9)

Disease log2 FC p
Waldenstrons macroglobulinemia 1.194 0.004
Multiple myeloma 1.603 0.000
astrocytic glioma -1.100 0.041
breast carcinoma 1.400 0.000
diabetes mellitus -2.900 0.002
Subcutaneous panniculitis-like T-cell ly... 1.300 0.030
invasive ductal carcinoma 1.800 0.001
acute myeloid leukemia 1.400 0.030
ovarian cancer 1.900 0.000


Accession Q99437 D3DPY5 Q6IB32 V-ATPase 21 kDa proteolipid subunit
Symbols ATP6F


  Ortholog (13)

Species Source
Chimp OMA EggNOG
Macaque OMA Inparanoid
Mouse OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum EggNOG Inparanoid
Platypus EggNOG Inparanoid
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid
C. elegans OMA EggNOG Inparanoid
Fruitfly EggNOG Inparanoid
S.cerevisiae OMA EggNOG

Gene RIF (4)

19460752 Knockdown of ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b (ATP6V0B) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells
17576770 there is an important role for physical association between aldolase and the A, B and E subunits of V-ATPase in the regulation of the proton pump
15249206 These studies show a Na(+)- and HCO(3)(-)-independent pH(cyt) regulatory mechanism in HLMVE cells that is mediated by pmV-ATPases.
12890556 proximal promoter region contains cis-acting elements required for expression in cancer cells

AA Sequence


Text Mined References (20)

PMID Year Title
22982048 2012 Lipofuscin is formed independently of macroautophagy and lysosomal activity in stress-induced prematurely senescent human fibroblasts.
17662945 2007 Coupling of rotation and catalysis in F(1)-ATPase revealed by single-molecule imaging and manipulation.
17576770 2007 Physical interaction between aldolase and vacuolar H+-ATPase is essential for the assembly and activity of the proton pump.
16959974 2006 The consensus coding sequences of human breast and colorectal cancers.
16710414 2006 The DNA sequence and biological annotation of human chromosome 1.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15249206 2004 Plasmalemmal V-H(+)-ATPases regulate intracellular pH in human lung microvascular endothelial cells.
14597263 2003 Neurotransmitter release: the dark side of the vacuolar-H+ATPase.
14580332 2003 Revised nomenclature for mammalian vacuolar-type H+ -ATPase subunit genes.
12890556 2003 Structural and functional characterization of two human V-ATPase subunit gene promoters.