Tclin CSF3R Granulocyte colony-stimulating factor receptor

Protein Summary

Description

Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface. The protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Alternatively spliced transcript variants have been described. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. [provided by RefSeq, Aug 2010]

Uniprot Accession IDs

• Q99062
• G-CSF receptor

Gene Name

• CSF3R

Ensembl ID

• ENST00000331941
• ENSP00000332180
• ENSG00000119535
• ENST00000361632
• ENSP00000355406
• ENST00000373103
• ENSP00000362195
• ENST00000373104
• ENSP00000362196
• ENST00000373106
• ENSP00000362198

Symbol

• GCSFR
• SCN7
• CD114
• GCSFR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.75
PubMedID	0.71
biological term	0.69
disease	0.63
kinase perturbation	0.6

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Granulocyte Colony-stimulating Factor Receptor

Protein / Defense/immunity Protein / Granulocyte Colony-stimulating Factor Receptor

DTO Classes

Protein / Signaling / Cytokine / Granulocyte Colony-stimulating Factor Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 301.61   (req: < 5)

Gene RIFs: 107   (req: <= 3)

Antibodies: 620   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 301.61   (req: >= 5)

Gene RIFs: 107   (req: > 3)

Antibodies: 620   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4