| Tbio | Histone-lysine N-methyltransferase SETDB2 |
Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis.
This gene encodes a member of a family of proteins that contain a methyl-CpG-binding domain (MBD) and a SET domain and function as histone methyltransferases. This protein is recruited to heterochromatin and plays a role in the regulation of chromosome segregation. This region is commonly deleted in chronic lymphocytic leukemia. Naturally-occuring readthrough transcription occurs from this gene to the downstream PHF11 (PHD finger protein 11) gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
This gene encodes a member of a family of proteins that contain a methyl-CpG-binding domain (MBD) and a SET domain and function as histone methyltransferases. This protein is recruited to heterochromatin and plays a role in the regulation of chromosome segregation. This region is commonly deleted in chronic lymphocytic leukemia. Naturally-occuring readthrough transcription occurs from this gene to the downstream PHF11 (PHD finger protein 11) gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| osteosarcoma | 7950 | 4.8e-09 |
| ovarian cancer | 8520 | 4.1e-06 |
| pituitary cancer | 1972 | 4.5e-05 |
| hepatocellular carcinoma | 547 | 1.6e-04 |
| medulloblastoma, large-cell | 6241 | 3.6e-04 |
| gastric cancer | 459 | 2.1e-03 |
| subependymal giant cell astrocytoma | 2287 | 3.3e-02 |
| Disease | log2 FC | p |
|---|---|---|
| gastric cancer | -1.600 | 2.1e-03 |
| hepatocellular carcinoma | -1.400 | 1.6e-04 |
| medulloblastoma, large-cell | -1.100 | 3.6e-04 |
| osteosarcoma | -3.330 | 4.8e-09 |
| ovarian cancer | -1.200 | 4.1e-06 |
| pituitary cancer | 1.300 | 4.5e-05 |
| subependymal giant cell astrocytoma | 1.313 | 3.3e-02 |
MGEKNGDAKTFWMELEDDGKVDFIFEQVQNVLQSLKQKIKDGSATNKEYIQAMILVNEATIINSSTSIKG 1 - 70 ASQKEVNAQSSDPMPVTQKEQENKSNAFPSTSCENSFPEDCTFLTTENKEILSLEDKVVDFREKDSSSNL 71 - 140 SYQSHDCSGACLMKMPLNLKGENPLQLPIKCHFQRRHAKTNSHSSALHVSYKTPCGRSLRNVEEVFRYLL 141 - 210 ETECNFLFTDNFSFNTYVQLARNYPKQKEVVSDVDISNGVESVPISFCNEIDSRKLPQFKYRKTVWPRAY 211 - 280 NLTNFSSMFTDSCDCSEGCIDITKCACLQLTARNAKTSPLSSDKITTGYKYKRLQRQIPTGIYECSLLCK 281 - 350 CNRQLCQNRVVQHGPQVRLQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLSRANTEKSYGIDENGRDEN 351 - 420 TMKNIFSKKRKLEVACSDCEVEVLPLGLETHPRTAKTEKCPPKFSNNPKELTVETKYDNISRIQYHSVIR 421 - 490 DPESKTAIFQHNGKKMEFVSSESVTPEDNDGFKPPREHLNSKTKGAQKDSSSNHVDEFEDNLLIESDVID 491 - 560 ITKYREETPPRSRCNQATTLDNQNIKKAIEVQIQKPQEGRSTACQRQQVFCDEELLSETKNTSSDSLTKF 561 - 630 NKGNVFLLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRNFPLVAFFTNRYVKARTELTWDYGYEAGTV 631 - 700 PEKEIFCQCGVNKCRKKIL 701 - 719 //
