Tbio | Histone-lysine N-methyltransferase SETDB2 |
Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis.
This gene encodes a member of a family of proteins that contain a methyl-CpG-binding domain (MBD) and a SET domain and function as histone methyltransferases. This protein is recruited to heterochromatin and plays a role in the regulation of chromosome segregation. This region is commonly deleted in chronic lymphocytic leukemia. Naturally-occuring readthrough transcription occurs from this gene to the downstream PHF11 (PHD finger protein 11) gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
This gene encodes a member of a family of proteins that contain a methyl-CpG-binding domain (MBD) and a SET domain and function as histone methyltransferases. This protein is recruited to heterochromatin and plays a role in the regulation of chromosome segregation. This region is commonly deleted in chronic lymphocytic leukemia. Naturally-occuring readthrough transcription occurs from this gene to the downstream PHF11 (PHD finger protein 11) gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Comments
Disease | Target Count | P-value |
---|---|---|
ovarian cancer | 8492 | 1.60138705939075E-9 |
osteosarcoma | 7933 | 4.80800526076912E-9 |
pituitary cancer | 1972 | 4.54914596323727E-5 |
hepatocellular carcinoma | 550 | 1.60903836150338E-4 |
medulloblastoma, large-cell | 6234 | 3.59520513142149E-4 |
gastric cancer | 436 | 0.0021469556436849 |
subependymal giant cell astrocytoma | 2287 | 0.0330888965563884 |
Disease | log2 FC | p |
---|---|---|
gastric cancer | -1.600 | 0.002 |
hepatocellular carcinoma | -1.400 | 0.000 |
osteosarcoma | -3.330 | 0.000 |
medulloblastoma, large-cell | -1.100 | 0.000 |
subependymal giant cell astrocytoma | 1.313 | 0.033 |
ovarian cancer | -1.500 | 0.000 |
pituitary cancer | 1.300 | 0.000 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Macaque | OMA EggNOG Inparanoid |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA EggNOG |
Dog | OMA EggNOG Inparanoid |
Horse | OMA EggNOG Inparanoid |
Cow | OMA EggNOG Inparanoid |
Pig | OMA EggNOG |
Opossum | OMA Inparanoid |
Platypus | OMA Inparanoid |
Chicken | OMA Inparanoid |
Anole lizard | OMA EggNOG Inparanoid |
Xenopus | OMA Inparanoid |
PMID | Text |
---|---|
26709698 | these findings identify Setdb2 as a novel regulator of the immune system in acute respiratory viral infection. |
26378653 | Results indicate that the IgE-associated AT/G polymorphism (rs386770867) regulates transcription of SETDB2. |
20404330 | Results provide evidence that CLLD8/KMT1F is recruited to heterochromatin regions and contributes in vivo to the deposition of trimethyl marks in concert with SUV39H1/KMT1A.SUV39H1/KMT1A. |
20085599 | Observational study of gene-disease association. (HuGE Navigator) |
18498648 | HIV-1 Tat associates with SETDB2 in vitro |
MGEKNGDAKTFWMELEDDGKVDFIFEQVQNVLQSLKQKIKDGSATNKEYIQAMILVNEATIINSSTSIKG 1 - 70 ASQKEVNAQSSDPMPVTQKEQENKSNAFPSTSCENSFPEDCTFLTTENKEILSLEDKVVDFREKDSSSNL 71 - 140 SYQSHDCSGACLMKMPLNLKGENPLQLPIKCHFQRRHAKTNSHSSALHVSYKTPCGRSLRNVEEVFRYLL 141 - 210 ETECNFLFTDNFSFNTYVQLARNYPKQKEVVSDVDISNGVESVPISFCNEIDSRKLPQFKYRKTVWPRAY 211 - 280 NLTNFSSMFTDSCDCSEGCIDITKCACLQLTARNAKTSPLSSDKITTGYKYKRLQRQIPTGIYECSLLCK 281 - 350 CNRQLCQNRVVQHGPQVRLQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLSRANTEKSYGIDENGRDEN 351 - 420 TMKNIFSKKRKLEVACSDCEVEVLPLGLETHPRTAKTEKCPPKFSNNPKELTVETKYDNISRIQYHSVIR 421 - 490 DPESKTAIFQHNGKKMEFVSSESVTPEDNDGFKPPREHLNSKTKGAQKDSSSNHVDEFEDNLLIESDVID 491 - 560 ITKYREETPPRSRCNQATTLDNQNIKKAIEVQIQKPQEGRSTACQRQQVFCDEELLSETKNTSSDSLTKF 561 - 630 NKGNVFLLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRNFPLVAFFTNRYVKARTELTWDYGYEAGTV 631 - 700 PEKEIFCQCGVNKCRKKIL 701 - 719 //
PMID | Year | Title |
---|---|---|
26709698 | 2015 | Type I Interferon Induced Epigenetic Regulation of Macrophages Suppresses Innate and Adaptive Immunity in Acute Respiratory Viral Infection. |
26572639 | 2016 | Left-Right Axis Differentiation and Functional Lateralization: a Haplotype in the Methyltransferase Encoding Gene SETDB2 Might Mediate Handedness in Healthy Adults. |
26378653 | 2015 | A functional AT/G polymorphism in the 5'-untranslated region of SETDB2 in the IgE locus on human chromosome 13q14. |
25416956 | 2014 | A proteome-scale map of the human interactome network. |
20404330 | 2010 | CLLD8/KMT1F is a lysine methyltransferase that is important for chromosome segregation. |
20085599 | 2009 | A multi-centre study of candidate genes for wheeze and allergy: the International Study of Asthma and Allergies in Childhood Phase 2. |
17974005 | 2007 | The full-ORF clone resource of the German cDNA Consortium. |
16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |
15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
15057823 | 2004 | The DNA sequence and analysis of human chromosome 13. |
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