Property Summary

NCBI Gene PubMed Count 11
PubMed Score 5.88
PubTator Score 5.01

Knowledge Summary

Patent (410)

TINX Plot

  Disease Relevance (2)

Gene RIF (2)

PMID Text
26239056 These findings reveal TALK-1 channels as important modulators of second-phase insulin secretion and suggest a clinically relevant mechanism for rs1535500, which may increase type 2 diabetes risk by limiting glucose-stimulated insulin secretion.
12724142 at least two functional TALK-1 variants are present and may serve as background K+ currents in certain cells of the human pancreas.

AA Sequence

MPSAGLCSCWGGRVLPLLLAYVCYLLLGATIFQLLERQAEAQSRDQFQLEKLRFLENYTCLDQWAMEQFV      1 - 70
QVIMEAWVKGVNPKGNSTNPSNWDFGSSFFFAGTVVTTIGYGNLAPSTEAGQVFCVFYALLGIPLNVIFL     71 - 140
NHLGTGLRAHLAAIERWEDRPRRSQVLQVLGLALFLTLGTLVILIFPPMVFSHVEGWSFSEGFYFAFITL    141 - 210
STIGFGDYVVGTDPSKHYISVYRSLAAIWILLGLAWLALILPLGPLLLHRCCQLWLLSLRQGCGAKAAPG    211 - 280
RRPRRGSTAARGVQVTPQDFPISKKGLGS                                             281 - 309
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Text Mined References (12)

PMID Year Title
26239056 2015 Type 2 Diabetes-Associated K+ Channel TALK-1 Modulates ?-Cell Electrical Excitability, Second-Phase Insulin Secretion, and Glucose Homeostasis.
25416956 2014 A proteome-scale map of the human interactome network.
24509480 2014 Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
22158537 2011 Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.
18516069 2008 Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein.
16382106 2005 International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14574404 2003 The DNA sequence and analysis of human chromosome 6.
12724142 2003 Functional properties of four splice variants of a human pancreatic tandem-pore K+ channel, TALK-1.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
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