Property Summary

NCBI Gene PubMed Count 15
Grant Count 4
R01 Count 4
Funding $242,727.5
PubMed Score 12.19
PubTator Score 9.07

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (20)

Disease log2 FC p
astrocytoma -2.900 0.001
ependymoma -4.500 0.000
oligodendroglioma -2.300 0.000
cutaneous lupus erythematosus 1.200 0.034
glioblastoma -4.500 0.000
osteosarcoma -2.416 0.000
group 4 medulloblastoma -4.900 0.000
atypical teratoid / rhabdoid tumor -5.000 0.000
medulloblastoma, large-cell -4.300 0.000
primitive neuroectodermal tumor -3.700 0.000
tuberculosis -1.100 0.000
non-small cell lung cancer -1.462 0.000
lung cancer -1.500 0.000
interstitial cystitis 2.300 0.001
pediatric high grade glioma -4.000 0.000
pilocytic astrocytoma -2.200 0.000
primary Sjogren syndrome 1.600 0.002
subependymal giant cell astrocytoma -3.581 0.002
invasive ductal carcinoma -1.400 0.011
ulcerative colitis 1.700 0.001

Synonym

Accession Q96T49 A2RRR6 E9PFS8 O94912 Q5W9G4 Q9NQG4
Symbols TIMAP
ANKRD4

Gene

Gene RIF (6)

PMID Text
26497934 ROCK phosphorylated eEF1A1 is a novel substrate for TIMAP-PP1 underlining the complex regulatory role of TIMAP in the endothelium.
25007873 TIMAP promotes angiogenesis by suppressing PTEN-mediated Akt inhibition in human glomerular endothelial cells.
21907835 These data confirmed the barrier-protective role of TIMAP
21466834 Data suggest that double-thiophosphorylation of TIMAP has minor effect on its binding ability to PP1c, but considerably attenuates its inhibitory effect on the activity of PP1c.
18586956 involvement of TIMAP in PKA-mediated moesin dephosphorylation and the importance of this dephosphorylation in TIMAP-mediated endothelial cell barrier protection
12055102 TIMAP, a novel CAAX box protein regulated by TGF-beta1 and expressed in endothelial cells.

AA Sequence

MASHVDLLTELQLLEKVPTLERLRAAQKRRAQQLKKWAQYEQDLQHRKRKHERKRSTGGRRKKVSFEASV      1 - 70
ALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHA     71 - 140
AATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKINEMRVAPEQQMIA    141 - 210
DIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAEL    211 - 280
LVSHGASLSARTSMDEMPIDLCEEEEFKVLLLELKHKHDVIMKSQLRHKSSLSRRTSSAGSRGKVVRRAS    281 - 350
LSDRTNLYRKEYEGEAILWQRSAAEDQRTSTYNGDIRETRTDQENKDPNPRLEKPVLLSEFPTKIPRGEL    351 - 420
DMPVENGLRAPVSAYQYALANGDVWKVHEVPDYSMAYGNPGVADATPPWSSYKEQSPQTLLELKRQRAAA    421 - 490
KLLSHPFLSTHLGSSMARTGESSSEGKAPLIGGRTSPYSSNGTSVYYTVTSGDPPLLKFKAPIEEMEEKV    491 - 560
HGCCRIS                                                                   561 - 567
//

Text Mined References (17)

PMID Year Title
27107012 2016 Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
26497934 2015 Elongation factor-1A1 is a novel substrate of the protein phosphatase 1-TIMAP complex.
25416956 2014 A proteome-scale map of the human interactome network.
25056061 2014 Biological insights from 108 schizophrenia-associated genetic loci.
25007873 2014 TIMAP promotes angiogenesis by suppressing PTEN-mediated Akt inhibition in human glomerular endothelial cells.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
21907835 2011 TIMAP protects endothelial barrier from LPS-induced vascular leakage and is down-regulated by LPS.
21466834 2011 Characterization of the effect of TIMAP phosphorylation on its interaction with protein phosphatase 1.
18586956 2008 TIMAP is a positive regulator of pulmonary endothelial barrier function.
16263087 2005 The protein phosphatase-1 targeting subunit TIMAP regulates LAMR1 phosphorylation.
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