Tbio DIRC2 Disrupted in renal carcinoma protein 2

Protein Summary

Description

Electrogenic metabolite transporter. This gene encodes a membrane-bound protein from the major facilitator superfamily of transporters. Disruption of this gene by translocation has been associated with haplo-insufficiency and renal cell carcinomas. Alternatively spliced transcript variants have been described, but their biological validity has not yet been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q96SL1
• A8K561
• Q8NBX9

Gene Name

• DIRC2

Ensembl ID

• ENST00000261038
• ENSP00000261038
• ENSG00000138463

Symbol

• RCC4
• DIRC2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
histone modification site profile	0.78
transcription factor binding site profile	0.7
transcription factor perturbation	0.61
transcription factor	0.6

Protein Classes

PANTHER Classes

Protein / Transporter / Disrupted In Renal Carcinoma Protein 2

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc49 Family Of Flvcr-related Heme Transporters / Disrupted In Renal Carcinoma Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.13   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 110   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.13   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0