| Tbio | Cyclin-L2 |
Involved in pre-mRNA splicing. May induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors.
The protein encoded by this gene belongs to the cyclin family. Through its interaction with several proteins, such as RNA polymerase II, splicing factors, and cyclin-dependent kinases, this protein functions as a regulator of the pre-mRNA splicing process, as well as in inducing apoptosis by modulating the expression of apoptotic and antiapoptotic proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
The protein encoded by this gene belongs to the cyclin family. Through its interaction with several proteins, such as RNA polymerase II, splicing factors, and cyclin-dependent kinases, this protein functions as a regulator of the pre-mRNA splicing process, as well as in inducing apoptosis by modulating the expression of apoptotic and antiapoptotic proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| glioblastoma multiforme | 142 | 2.6e-16 |
| ovarian cancer | 8520 | 1.0e-08 |
| Pick disease | 1894 | 3.7e-07 |
| acute quadriplegic myopathy | 1158 | 4.2e-07 |
| malignant mesothelioma | 3232 | 5.6e-06 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 1.1e-03 |
| lung adenocarcinoma | 2716 | 1.2e-03 |
| psoriasis | 6694 | 1.3e-03 |
| osteosarcoma | 7950 | 2.4e-03 |
| oligodendroglioma | 2850 | 4.3e-03 |
| astrocytic glioma | 2597 | 4.7e-03 |
| progressive supranuclear palsy | 676 | 4.9e-03 |
| group 3 medulloblastoma | 4104 | 7.4e-03 |
| ependymoma | 4679 | 8.2e-03 |
| Disease | log2 FC | p |
|---|---|---|
| acute quadriplegic myopathy | 1.101 | 4.2e-07 |
| astrocytic glioma | 1.700 | 4.7e-03 |
| ependymoma | 1.800 | 8.2e-03 |
| glioblastoma multiforme | 1.100 | 2.6e-16 |
| group 3 medulloblastoma | 1.400 | 7.4e-03 |
| lung adenocarcinoma | 1.100 | 1.2e-03 |
| malignant mesothelioma | -1.100 | 5.6e-06 |
| oligodendroglioma | 1.100 | 4.3e-03 |
| osteosarcoma | -1.041 | 2.4e-03 |
| ovarian cancer | -1.900 | 1.0e-08 |
| pancreatic ductal adenocarcinoma liver m... | 1.730 | 1.1e-03 |
| Pick disease | -1.900 | 3.7e-07 |
| progressive supranuclear palsy | -1.500 | 4.9e-03 |
| psoriasis | -1.200 | 1.3e-03 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG |
MAAAAAAAGAAGSAAPAAAAGAPGSGGAPSGSQGVLIGDRLYSGVLITLENCLLPDDKLRFTPSMSSGLD 1 - 70 TDTETDLRVVGCELIQAAGILLRLPQVAMATGQVLFQRFFYTKSFVKHSMEHVSMACVHLASKIEEAPRR 71 - 140 IRDVINVFHRLRQLRDKKKPVPLLLDQDYVNLKNQIIKAERRVLKELGFCVHVKHPHKIIVMYLQVLECE 141 - 210 RNQHLVQTSWNYMNDSLRTDVFVRFQPESIACACIYLAARTLEIPLPNRPHWFLLFGATEEEIQEICLKI 211 - 280 LQLYARKKVDLTHLEGEVEKRKHAIEEAKAQARGLLPGGTQVLDGTSGFSPAPKLVESPKEGKGSKPSPL 281 - 350 SVKNTKRRLEGAKKAKADSPVNGLPKGRESRSRSRSREQSYSRSPSRSASPKRRKSDSGSTSGGSKSQSR 351 - 420 SRSRSDSPPRQAPRSAPYKGSEIRGSRKSKDCKYPQKPHKSRSRSSSRSRSRSRERADNPGKYKKKSHYY 421 - 490 RDQRRERSRSYERTGRRYERDHPGHSRHRR 491 - 520 //
