Property Summary

NCBI Gene PubMed Count 85
PubMed Score 82.79
PubTator Score 151.08

Knowledge Summary

Patent (7,609)


  Disease Sources (3)

Disease Target Count P-value
non-small cell lung cancer 2798 3.27285517950202E-12
malignant mesothelioma 3163 7.11580296610752E-8
pituitary cancer 1972 1.7698979363969E-5
psoriasis 6685 2.24660757212427E-4
ductal carcinoma in situ 1745 7.51707699340009E-4
cystic fibrosis 1670 0.00133389389353371
invasive ductal carcinoma 2950 0.00194908349285932
osteosarcoma 7933 0.00323027125719372
fibroadenoma 557 0.00372848895995184
breast carcinoma 1614 0.00575082389617079
adrenocortical carcinoma 1427 0.00788625365431183
Polycystic Ovary Syndrome 335 0.0171715882815304
non primary Sjogren syndrome sicca 840 0.0189771508080268
X-linked cerebral adrenoleukodystrophy 115 0.035803723958859
Disease Target Count Z-score Confidence
diabetes mellitus 1663 3.364 1.7


  Differential Expression (14)

Disease log2 FC p
malignant mesothelioma 2.500 0.000
psoriasis 2.300 0.000
osteosarcoma 1.392 0.003
adrenocortical carcinoma 1.165 0.008
non-small cell lung cancer 1.146 0.000
X-linked cerebral adrenoleukodystrophy 2.100 0.036
breast carcinoma 1.100 0.006
fibroadenoma 1.200 0.004
cystic fibrosis 1.100 0.001
non primary Sjogren syndrome sicca 1.100 0.019
Polycystic Ovary Syndrome -1.391 0.017
ductal carcinoma in situ 1.900 0.001
invasive ductal carcinoma 2.300 0.002
pituitary cancer -2.000 0.000


Accession Q96RU7 Q53GU4 Q53ZW7 Q6I9Y9 Q8TAI6 Q9H5M8 Q9NUD2 TRB-3
Symbols NIPK


PANTHER Protein Class (3)

  Ortholog (9)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG
Cow OMA EggNOG Inparanoid
Opossum EggNOG Inparanoid
Anole lizard EggNOG Inparanoid

Gene RIF (74)

26584255 TRB3 is upregulated in macrophages upon treatment with ox-LDL. TRB3 promotes lipid accumulation and suppresses cytokine expression, suggesting inflammation and foam cell formation can be reciprocally regulated.
26517935 Studies show that tribbles pseudokinase 3 (TRIB3) plays a crucial role in the anti-cancer activity of cannabinoids and that TRIB3 genetic inactivation enhances cancer generation and progression.
26517934 Studies show a remarkable reduction in tribbles 2 protein (Trib2) expression during oocyte maturation whereas tribbles 1 protein (Trib1) and tribbles 3 protein (Trib3) expression was significantly increased during this process.
26517932 Studies suggest that the tribbles homolog 3 (Drosophila) protein (TRIB3) Q84R missense polymorphis contributes to atherosclerosis.
26517930 Studies indicate that small molecules can reveal rate-limiting signalling outputs and functions of pseudo-kinase family of tribbles (TRIB) proteins TRIB1, TRIB2 and TRIB3 in cells and intact organisms, serving as guides for the development of new drugs.
26517925 Studies suggest that pseudo-kinase family of tribbles (TRIB) proteins TRIB1, TRIB2 and TRIB3 were involved in the pathogenesis of inflammation.
26517922 Studies suggest that pseudo-kinase family of tribbles (TRIB) proteins TRIB1, TRIB2 and TRIB3 play roles in pathogenesis of rheumatoid arthritis (RA) and osteoarthritis.
26253791 Suggest a role of TRIB3 low-frequency variants on coronary artery disease risk among Italian patients with T2D.
26224857 Trib3 interferes with the Parkinson's disease-associated prosurvival protein Parkin to mediate death
26094770 These results implicate TRIB3 and IGFBP2, both of which are known to be overexpressed in several types of cancers, as pro-survival modulators of cell viability in nutrient-deficient microenvironments.

AA Sequence

DREVVLYG                                                                  351 - 358

Text Mined References (87)

PMID Year Title
26584255 2016 Tribbles Homolog 3 Promotes Foam Cell Formation Associated with Decreased Proinflammatory Cytokine Production in Macrophages: Evidence for Reciprocal Regulation of Cholesterol Uptake and Inflammation.
26517935 2015 Oncosuppressive functions of tribbles pseudokinase 3.
26517934 2015 Tribbles role in reproduction.
26517932 2015 The TRIB3 Q84R polymorphism, insulin resistance and related metabolic alterations.
26517930 2015 Tribbles pseudokinases: novel targets for chemical biology and drug discovery?
26517925 2015 Tribbles in inflammation.
26517922 2015 Tribbles and arthritis: what are the links?
26253791 2015 Infrequent TRIB3 coding variants and coronary artery disease in type 2 diabetes.
26224857 2015 Trib3 Is Elevated in Parkinson's Disease and Mediates Death in Parkinson's Disease Models.
26094770 2015 TRIB3 enhances cell viability during glucose deprivation in HEK293-derived cells by upregulating IGFBP2, a novel nutrient deficiency survival factor.