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  5. A (Shaker) subfamily
  6. Kv1.7/KCNA7 sub-subfamily
  7. Potassium voltage-gated channel subfamily A member 7

Tclin Potassium voltage-gated channel subfamily A member 7

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (By similarity).

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. The gene is expressed preferentially in skeletal muscle, heart and kidney. It is a candidate gene for inherited cardiac disorders. [provided by RefSeq, Jul 2008]

 Comments

Property Summary

NCBI Gene PubMed Count 7
PubMed Score 7.71
PubTator Score 7.45

Knowledge Summary

Patent (1,898)

TINX Plot

  Disease Relevance (2)

Disease Z-score Confidence
Eaton-Lambert syndrome 40
Multiple Sclerosis 498

Expression

Synonym

Accession Q96RP8 A1KYX7 Q9BYS4
Symbols HAK6
KV1.7

Gene

KCNA7

PANTHER Protein Class (4)

 Collection (1)

 GO Function (1)

 GO Component (3)

 GO Process (1)

 Compartment GO Term (9)

Pathway (3)

 UniProt Keyword (16)

See all...

Drug (3)

Structure of guanidine

guanidine

Structure of fampridine

fampridine

Structure of amifampridine

amifampridine

Ligand (1)

Structure of CHEMBL2442509

CHEMBL2442509
pIC50 7.23

Gene RIF (3)

PMID Text
22438204 The authors conclude that K(v) 1.7 contributes to the membrane-repolarizing current of beta cells during glucose-stimulated insulin.
15639836 Observational study of genotype prevalence. (HuGE Navigator)
11896454 Expressed in heart, but not the cause of progressive familial heart block I.

AA Sequence 

MEPRCPPPCGCCERLVLNVAGLRFETRARTLGRFPDTLLGDPARRGRFYDDARREYFFDRHRPSFDAVLY      1 - 70
YYQSGGRLRRPAHVPLDVFLEEVAFYGLGAAALARLREDEGCPVPPERPLPRRAFARQLWLLFEFPESSQ     71 - 140
AARVLAVVSVLVILVSIVVFCLETLPDFRDDRDGTGLAAAAAAGPFPAPLNGSSQMPGNPPRLPFNDPFF    141 - 210
VVETLCICWFSFELLVRLLVCPSKAIFFKNVMNLIDFVAILPYFVALGTELARQRGVGQQAMSLAILRVI    211 - 280
RLVRVFRIFKLSRHSKGLQILGQTLRASMRELGLLIFFLFIGVVLFSSAVYFAEVDRVDSHFTSIPESFW    281 - 350
WAVVTMTTVGYGDMAPVTVGGKIVGSLCAIAGVLTISLPVPVIVSNFSYFYHRETEGEEAGMFSHVDMQP    351 - 420
CGPLEGKANGGLVDGEVPELPPPLWAPPGKHLVTEV                                      421 - 456
//

Text Mined References (7)

PMID Year Title
22438204 2012 Block of Kv1.7 potassium currents increases glucose-stimulated insulin secretion.
16382104 2005 International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.
15639836 2003 [Distribution and significance of cSNP in KCNA7 gene as a novel NIDDM candidate gene in the population of northeast China].
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11896454 2002 Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI).
11368907 2001 Initial isolation and analysis of the human Kv1.7 (KCNA7) gene, a member of the voltage-gated potassium channel gene family.
9488722 1998 Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7.