Tbio | Tumor necrosis factor receptor superfamily member 13C |
B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.
B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008]
B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008]
Comments
Disease | Target Count |
---|---|
Immunodeficiency, common variable, 4 | 1 |
Disease | Target Count | P-value |
---|---|---|
osteosarcoma | 7933 | 2.97938366083588E-9 |
primary Sjogren syndrome | 789 | 3.08879843205335E-5 |
tuberculosis | 1563 | 4.61660608678951E-4 |
nasopharyngeal carcinoma | 1056 | 5.03269093737133E-4 |
interstitial cystitis | 2299 | 0.00111286857028908 |
ulcerative colitis | 2087 | 0.0118641071787445 |
sonic hedgehog group medulloblastoma | 1482 | 0.01602124061573 |
ductal carcinoma in situ | 1745 | 0.0226893389662835 |
primitive neuroectodermal tumor | 3031 | 0.0257341480916734 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Common variable immunodeficiency | 98 | 5.305 | 2.7 |
Disease | log2 FC | p |
---|---|---|
osteosarcoma | -3.329 | 0.000 |
primitive neuroectodermal tumor | 1.400 | 0.026 |
tuberculosis | -1.500 | 0.000 |
interstitial cystitis | 3.800 | 0.001 |
sonic hedgehog group medulloblastoma | 1.100 | 0.016 |
primary Sjogren syndrome | 3.000 | 0.000 |
nasopharyngeal carcinoma | -2.200 | 0.001 |
ductal carcinoma in situ | 2.000 | 0.023 |
ulcerative colitis | 2.200 | 0.012 |
Accession | Q96RJ3 |
Symbols |
BAFFR CD268 CVID4 BAFF-R BROMIX prolixin |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA Inparanoid |
Dog | OMA EggNOG |
Horse | OMA EggNOG Inparanoid |
Cow | OMA EggNOG |
Chicken | OMA Inparanoid |
PMID | Text |
---|---|
26613719 | genetic polymorphism contributes to the pathogenesis of primary antibody deficiency |
26327569 | Negative expression of BAFF-R, but not of BAFF, could be an independent risk factor for progression-free survival and Overall survival in patients with diffuse large B-cell lymphoma treated with standard R-CHOP. |
26214745 | BAFF and BAFF-R are expressed in the thyrocytes derived from patients with either autoimmune thyroid disorders or multinodular goiter, as well in the infiltrating immune cells of Graves' disease and Hashimoto's thyroiditis |
26122175 | Variants of TNFRSF13C were associated with common variable immunodeficiency. |
26097183 | There is an increased prevalence of the BAFF-R His159Tyr mutation in patients with Sjogren's syndrome (SS), particularly in those with SS complicated by MALT lymphoma whose disease onset occurred at a younger age. |
25569260 | Expression of mutant caspase-9 correlated with a downregulation of BAFFR (B-cell-activating factor belonging to the TNF family (BAFF) receptor) in B cells and ICOS (inducible T-cell costimulator) in T cells. |
25454804 | the common TLR4-D299G, TLR4-T399I and BAFFR-P21R polymorphisms provide the carriers with a protective advantage against ICU-acquired sepsis; this finding was more profound for medical patients compared to trauma or surgical ones |
25301447 | Data show significant differences in expression of tumour necrosis factor family (BAFF) receptors BAFF-R, BCMA and TACI in patients with and without anti-Jo-1 or anti-Ro52/anti-Ro60 autoantibodies. |
24825858 | In view of the restricted expression of the BAFF-R on normal cells and the multiple anti-pre-B ALL activities stimulated by this antibody, a further examination of its use for treatment of pre-B ALL is warranted. |
24809296 | Availability of BAFF determines BAFF-R and TACI expression on B cells in common variable immunodeficiency. |
More... |
PMID | Year | Title |
---|---|---|
26613719 | 2016 | Monoallelic BAFFR P21R/H159Y Mutations and Familiar Primary Antibody Deficiencies. |
26327569 | 2015 | Expression of BAFF-R, but not BAFF, is an independent prognostic factor in diffuse large B-cell lymphoma patients treated with R-CHOP. |
26214745 | 2015 | B Cell Activating Factor (BAFF) and BAFF Receptor Expression in Autoimmune and Nonautoimmune Thyroid Diseases. |
26122175 | 2015 | Application of whole genome and RNA sequencing to investigate the genomic landscape of common variable immunodeficiency disorders. |
26097183 | 2015 | A BAFF receptor His159Tyr mutation in Sjögren's syndrome-related lymphoproliferation. |
25569260 | 2015 | A mutation in caspase-9 decreases the expression of BAFFR and ICOS in patients with immunodeficiency and lymphoproliferation. |
25454804 | 2015 | Genetic polymorphisms of innate and adaptive immunity as predictors of outcome in critically ill patients. |
25301447 | 2014 | Expression of BAFF receptors in muscle tissue of myositis patients with anti-Jo-1 or anti-Ro52/anti-Ro60 autoantibodies. |
25056061 | 2014 | Biological insights from 108 schizophrenia-associated genetic loci. |
24825858 | 2014 | Effector-mediated eradication of precursor B acute lymphoblastic leukemia with a novel Fc-engineered monoclonal antibody targeting the BAFF-R. |
More... |