Tclin TAAR1 Trace amine-associated receptor 1

Protein Summary

Description

Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonin. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase. The protein encoded by this gene is a G-protein coupled receptor activated by trace amines. The encoded protein responds little or not at all to dopamine, serotonin, epinephrine, or histamine, but responds well to beta-phenylethylamine, p-tyramine, octopamine, and tryptamine. While primarily functioning in neurologic systems, there is evidence that this gene is involved in blood cell and immunologic functions as well. This gene is thought to be intronless. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• Q96RJ0
• Q2M1W5
• Q3MIH8
• Q5VUQ1
• TaR-1

Gene Name

• TAAR1

Ensembl ID

• ENST00000275216
• ENSP00000275216
• ENSG00000146399

Symbol

• TA1
• TAR1
• TRAR1
• TA1
• TAR1
• TRAR1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.78
gene perturbation	0.71
cell line	0.61
protein domain	0.58
chemical	0.5

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Trace Amine-associated Receptor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 791.32   (req: < 5)

Gene RIFs: 27   (req: <= 3)

Antibodies: 162   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 791.32   (req: >= 5)

Gene RIFs: 27   (req: > 3)

Antibodies: 162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 70

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4