Property Summary

NCBI Gene PubMed Count 19
PubMed Score 52.34
PubTator Score 27.97

Knowledge Summary

Patent (3,286)

TINX Plot

  Disease Sources (1)

Disease Target Count P-value
pilocytic astrocytoma 3086 2.15162818465239E-12
posterior fossa group A ependymoma 1511 2.56445919878714E-11
glioblastoma 5572 4.84415761410143E-11
atypical teratoid / rhabdoid tumor 4369 5.89098437921631E-11
sonic hedgehog group medulloblastoma 1482 2.09621567549324E-8
medulloblastoma, large-cell 6234 4.52566269249363E-8
adult high grade glioma 2148 1.08739763506797E-7
osteosarcoma 7933 1.13027984768207E-4
primitive neuroectodermal tumor 3031 8.86899515972129E-4
subependymal giant cell astrocytoma 2287 0.010509796343956
Multiple Sclerosis 498 0.0229335809593585

Expression

Synonym

Accession Q96RD6 B7Z684 Q96RD5 Q9UGX8
Symbols PX2
hPANX2

Gene

  Ortholog (13)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG
Zebrafish OMA Inparanoid

Gene RIF (9)

PMID Text
25773474 There is dense expression of Panx2 in the enteric nervous system. The substantial increase in Panx2 mRNA in ulcerative colitis (UC) muscle but not protein suggests that the Panx2 translation process may be disrupted in UC.
25008946 Data suggest that both up-regulation and down-regulation of expression of pannexins (PANX1, PANX2, PANX3) are associated with disease onset and/or progression; examples include neoplasms, multiple sclerosis, migraine, and hypertension. [REVIEW]
24146091 Panx1 and Panx2 expression was detected in the temporal lobe cortex of patients with temporal lobe epilepsy and in the control tissues.
20516070 Pannexin1 and Pannexin2 channels show quaternary similarities to connexons and different oligomerization numbers from each other
20198315 Observational study of gene-disease association. (HuGE Navigator)
19851296 Observational study of gene-disease association. (HuGE Navigator)
19749789 Pannexin2 is a tumor suppressor gene in C6 glioma cells.
17427027 These data do not suggest that Panx2 or Cx36 could increase the risk of schizophrenia in the Japanese population.
16989724 According to brain cancer gene expression database REMBRANDT, PANX2 expression levels can predict post diagnosis survival for patients with glial tumors.

AA Sequence

MHHLLEQSADMATALLAGEKLRELILPGAQDDKAGALAALLLQLKLELPFDRVVTIGTVLVPILLVTLVF      1 - 70
TKNFAEEPIYCYTPHNFTRDQALYARGYCWTELRDALPGVDASLWPSLFEHKFLPYALLAFAAIMYVPAL     71 - 140
GWEFLASTRLTSELNFLLQEIDNCYHRAAEGRAPKIEKQIQSKGPGITEREKREIIENAEKEKSPEQNLF    141 - 210
EKYLERRGRSNFLAKLYLARHVLILLLSAVPISYLCTYYATQKQNEFTCALGASPDGAAGAGPAVRVSCK    211 - 280
LPSVQLQRIIAGVDIVLLCVMNLIILVNLIHLFIFRKSNFIFDKLHKVGIKTRRQWRRSQFCDINILAMF    281 - 350
CNENRDHIKSLNRLDFITNESDLMYDNVVRQLLAALAQSNHDATPTVRDSGVQTVDPSANPAEPDGAAEP    351 - 420
PVVKRPRKKMKWIPTSNPLPQPFKEPLAIMRVENSKAEKPKPARRKTATDTLIAPLLDRSAHHYKGGGGD    421 - 490
PGPGPAPAPAPPPAPDKKHARHFSLDVHPYILGTKKAKAEAVPAALPASRSQEGGFLSQAEDCGLGLAPA    491 - 560
PIKDAPLPEKEIPYPTEPARAGLPSGGPFHVRSPPAAPAVAPLTPASLGKAEPLTILSRNATHPLLHINT    561 - 630
LYEAREEEDGGPRLPQDVGDLIAIPAPQQILIATFDEPRTVVSTVEF                           631 - 677
//

Text Mined References (20)

PMID Year Title
25773474 2015 Pannexin-2 is expressed in the human colon with extensive localization in the enteric nervous system.
25008946 2014 Pannexin channels and their links to human disease.
24927181 2014 Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
24146091 2013 Altered expression of pannexin proteins in patients with temporal lobe epilepsy.
20516070 2010 Pannexin1 and Pannexin2 channels show quaternary similarities to connexons and different oligomerization numbers from each other.
20198315 2010 Association of genetic variants with hemorrhagic stroke in Japanese individuals.
19851296 2010 Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.
19749789 2009 Pannexin2 as a novel growth regulator in C6 glioma cells.
17474147 2007 Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.
17427027 2007 Gap junction coding genes and schizophrenia: a genetic association study.
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