Tbio RBP7 Retinoid-binding protein 7

Protein Summary

Description

Intracellular transport of retinol. The protein encoded by this gene is a member of the cellular retinol-binding protein (CRBP) family, whose members are required for vitamin A stability and metabolism. The encoded protein binds all-trans-retinol and is structurally similar to other CRBPs; however, it has a lower binding affinity for retinol than other CRBPs. [provided by RefSeq, Aug 2016]

Uniprot Accession IDs

• Q96R05
• B2R517
• Q5SWJ4

Gene Name

• RBP7

Ensembl ID

• ENST00000294435
• ENSP00000294435
• ENSG00000162444

Symbol

• CRBP4
• CRABP4
• CRBPIV

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.76
cell type or tissue	0.74
tissue sample	0.67
small molecule perturbation	0.63
protein domain	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.68   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 118   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.68   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0